Direct arylation of thiazoles on water

Gemma L. Turner; James A. Morris; Michael F. Greaney

doi:10.1002/anie.200702141

Direct arylation of thiazoles on water

Gemma L. Turner, James A. Morris, Michael F. Greaney

Research output: Contribution to journal › Article › peer-review

Abstract

Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	7996-8000
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	42
DOIs	https://doi.org/10.1002/anie.200702141
Publication status	Published - 2007

Keywords

Direct arylation
Heterocycles
Homogeneous catalysis
Palladium
Water chemistry

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title = "Direct arylation of thiazoles on water",

abstract = "Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented). {\textcopyright} 2007 Wiley-VCH Verlag GmbH \& Co. KGaA.",

keywords = "Direct arylation, Heterocycles, Homogeneous catalysis, Palladium, Water chemistry",

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AU - Turner, Gemma L.

AU - Morris, James A.

AU - Greaney, Michael F.

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PY - 2007

Y1 - 2007

N2 - Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Direct arylation

KW - Heterocycles

KW - Homogeneous catalysis

KW - Palladium

KW - Water chemistry

U2 - 10.1002/anie.200702141

DO - 10.1002/anie.200702141

M3 - Article

SN - 1433-7851

VL - 46

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EP - 8000

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 42

ER -

Direct arylation of thiazoles on water

Abstract

Keywords

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