Direct assembly of nucleoside precursors from two- and three-carbon units

Carole Anastasi, Michael A. Crowe, Matthew W. Powner, John D. Sutherland

    Research output: Contribution to journalArticlepeer-review

    Abstract

    (Chemical Equation Presented) Sweetness and life: Pentose aminooxazolines - intermediates in potentially prebiotic nucleoside synthesis - can be produced in water from a reaction that bypasses the corresponding sugar. 2-Aminooxazole, a condensation product of glycolaldehyde and cyanamide, reacts with glyceraldehyde under mild conditions in a remarkable process that is essentially quantitative, and is highly stereoselective for ribose and arabinose aminooxazolines. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)6176-6179
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Volume45
    Issue number37
    DOIs
    Publication statusPublished - 18 Sept 2006

    Keywords

    • Carbohydrates
    • Nucleobases
    • Nucleosides
    • Prebiotic chemistry
    • Ribose

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