Direct synthesis of sulfonated azacalixarenes in water

Jonathan Clayden, Stephen J M Rowbottom, Warren J. Ebenezer, Michael G. Hutchings

    Research output: Contribution to journalArticlepeer-review


    Successive treatment of cyanuric chloride with two aromatic diamines, at least one of them sulfonated, yields water-soluble sulfonated azacalix[4]arenes which may be isolated by crystallisation. Functionalised azacalixarenes may be made by first displacing two chloro substituents from the cyclisation precursor. Attempted formation of an azacalix[6]arene led to a dimeric species for which two structures may be proposed, one of them an azacalixarene catenane. © The Royal Society of Chemistry 2009.
    Original languageEnglish
    Pages (from-to)4871-4880
    Number of pages9
    JournalOrganic and Biomolecular Chemistry
    Issue number23
    Publication statusPublished - 2009


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