Directing the morphology and differentiation of skeletal muscle cells using oriented cellulose nanowhiskers

James M. Dugan, Julie E. Gough, Stephen J. Eichhorn

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Radially oriented submonolayer surfaces of 10-15 nm diameter cellulose nanowhiskers (CNWs) were prepared by spin-coating. The response of myoblasts (muscle cells) to the surfaces was assessed using atomic force microscopy (AFM), immunocytochemistry, and image analysis. Despite the small size of the CNWs, the myoblasts oriented along the CNW surfaces. Upon differentiation, the myoblasts produced striking radial patterns of myotubes, following the radial pattern of the CNWs. This facile method of nanopatterning surfaces may be applied where the directed growth of tissue is required and shows for the first time the potential of CNWs for tissue engineering applications. © 2010 American Chemical Society.
    Original languageEnglish
    Pages (from-to)2498-2504
    Number of pages6
    JournalBiomacromolecules
    Volume11
    Issue number9
    DOIs
    Publication statusPublished - 13 Sept 2010

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