Discovery and Recovery of delta p-aminobenzoic acid

Martin R. Ward; Shatha Younis; Aurora J. Cruz-Cabeza; Craig L Bull; Nicholas P. Funnell; Iain Oswald

doi:10.1039/c8ce01882k

Discovery and Recovery of delta p-aminobenzoic acid

Martin R. Ward, Shatha Younis, Aurora J. Cruz-Cabeza, Craig L Bull, Nicholas P. Funnell, Iain Oswald

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Abstract

We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.

Original language	English
Journal	CrystEngComm
Early online date	21 Jan 2019
DOIs	https://doi.org/10.1039/c8ce01882k
Publication status	Published - 2019

Keywords

p-aminobenzoic acid
neutron powder diffraction
high pressure
recovery

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Discovery and Recovery of delta pabaAccepted author manuscript, 1.06 MB

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title = "Discovery and Recovery of delta p-aminobenzoic acid",

abstract = "We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.",

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author = "Ward, {Martin R.} and Shatha Younis and Cruz-Cabeza, {Aurora J.} and Bull, {Craig L} and Funnell, {Nicholas P.} and Iain Oswald",

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language = "English",

journal = "CrystEngComm",

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T1 - Discovery and Recovery of delta p-aminobenzoic acid

AU - Ward, Martin R.

AU - Younis, Shatha

AU - Cruz-Cabeza, Aurora J.

AU - Bull, Craig L

AU - Funnell, Nicholas P.

AU - Oswald, Iain

PY - 2019

Y1 - 2019

N2 - We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.

AB - We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.

KW - p-aminobenzoic acid

KW - neutron powder diffraction

KW - high pressure

KW - recovery

U2 - 10.1039/c8ce01882k

DO - 10.1039/c8ce01882k

M3 - Article

SN - 1466-8033

JO - CrystEngComm

JF - CrystEngComm

ER -

Discovery and Recovery of delta p-aminobenzoic acid

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Keywords

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