Abstract
Human flap endonuclease 1 (hFEN1) is instrumental in DNA replication and repair. It is able to cleave the 5' single-stranded protrusion (also known as 5' flap) resulting from strand displacement reactions. In light of its crucial functions, hFEN1 is now deemed as a nontrivial target in the DNA damage response system for anticancer drug development. Herein, we report that myricetin and some natural flavonoids are able to inhibit hFEN1. Structure-activity relationship, inhibitory mechanisms, molecular docking, and cancer cell-based assays have been performed. Our original findings expand the activity of flavonoids and may pave the way for flavonoid-assisted targeted cancer therapy.
Original language | English |
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Article number | 10.1021/acs.jafc.8b05447 |
Pages (from-to) | 1656 |
Number of pages | 1665 |
Journal | Journal of Agricultural and Food Chemistry |
Early online date | 29 Jan 2019 |
DOIs | |
Publication status | Published - 19 Feb 2019 |