@article{494c1f2e668e4e0aaedadedea2678d95,
title = "Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum",
abstract = "Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a {"}Super Smeller{"} who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (n=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our Super Smeller.",
author = "Trivedi, {Drupad K.} and Eleanor Sinclair and Yun Xu and Depanjan Sarkar and Caitlin Walton-Doyle and Camilla Liscio and Phine Banks and Joy Milne and Monty Silverdale and Tilo Kunath and Royston Goodacre and Perdita Barran",
note = "Funding Information: †Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN ‡Anatune, 4 Wellbrook Way, Girton, Cambridge, U.K., CB3 0NA §Department of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, U.K., M6 8HD ∥Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, U.K., EH16 4UU ⊥Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, U.K., L69 7ZB Funding Information: We thank Michael J Fox Foundation and Parkinson{\textquoteright}s UK for funding this study. We also thank our nationwide NIHR recruitment centers for their enthusiasm and rigor during the recruitment process. We are very grateful to all the participants who took part in this study as well as PIs and nurses across all the recruiting centers who helped us with the recruitment of participants. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = mar,
day = "20",
doi = "10.1021/acscentsci.8b00879",
language = "English",
volume = "5",
pages = "599--606",
journal = "ACS Central Science",
issn = "2374-7943",
publisher = "American Chemical Society",
number = "4",
}