Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.

Megan K Herbert; Judith Stammen-Vogelzangs; Marcel M Verbeek; Anke Rietveld; Ingrid E Lundberg; Hector Chinoy; Janine A Lamb; Robert G Cooper; Mark Roberts; Umesh A Badrising; Jan L De Bleecker; Pedro M Machado; Michael G Hanna; Lenka Plestilova; Jiri Vencovsky; Baziel G van Engelen; Ger J M Pruijn

doi:10.1136/annrheumdis-2014-206691

Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.

Megan K Herbert, Judith Stammen-Vogelzangs, Marcel M Verbeek, Anke Rietveld, Ingrid E Lundberg, Hector Chinoy, Janine A Lamb, Robert G Cooper, Mark Roberts, Umesh A Badrising, Jan L De Bleecker, Pedro M Machado, Michael G Hanna, Lenka Plestilova, Jiri Vencovsky, Baziel G van Engelen, Ger J M Pruijn

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. METHODS: Serum samples obtained from patients with IBM (n=238), PM and dermatomyositis (DM) (n=185), other autoimmune diseases (n=246), other neuromuscular diseases (n=93) and healthy controls (n=35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. RESULTS: Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37%) but not in PM, DM or non-autoimmune neuromuscular diseases (

Original language	English
Pages (from-to)	696-701
Journal	Annals of the rheumatic diseases
Volume	75
Issue number	4
DOIs	https://doi.org/10.1136/annrheumdis-2014-206691
Publication status	Published - 24 Feb 2015

Keywords

Autoantibodies
Autoimmune Diseases
Dermatomyositis
Polymyositis

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10.1136/annrheumdis-2014-206691

MMRG: Manchester Myositis Research Group
Chinoy, H. (PI), Lamb, J. (PI), Ollier, W. (PI), Rothwell, S. (CoI), Lilleker, J. (CoI), Oldroyd, A. (PGR student), Snedden, A. (PGR student), Platt, H. (Support team) & New, P. (Support team)
1/01/10 → …
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Herbert, M. K., Stammen-Vogelzangs, J., Verbeek, M. M., Rietveld, A., Lundberg, I. E., Chinoy, H., Lamb, J. A., Cooper, R. G., Roberts, M., Badrising, U. A., De Bleecker, J. L., Machado, P. M., Hanna, M. G., Plestilova, L., Vencovsky, J., van Engelen, B. G., & Pruijn, G. J. M. (2015). Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases. Annals of the rheumatic diseases, 75(4), 696-701. https://doi.org/10.1136/annrheumdis-2014-206691

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title = "Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.",

abstract = "OBJECTIVES: The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. METHODS: Serum samples obtained from patients with IBM (n=238), PM and dermatomyositis (DM) (n=185), other autoimmune diseases (n=246), other neuromuscular diseases (n=93) and healthy controls (n=35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. RESULTS: Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37\%) but not in PM, DM or non-autoimmune neuromuscular diseases (",

keywords = "Autoantibodies, Autoimmune Diseases, Dermatomyositis, Polymyositis",

author = "Herbert, \{Megan K\} and Judith Stammen-Vogelzangs and Verbeek, \{Marcel M\} and Anke Rietveld and Lundberg, \{Ingrid E\} and Hector Chinoy and Lamb, \{Janine A\} and Cooper, \{Robert G\} and Mark Roberts and Badrising, \{Umesh A\} and \{De Bleecker\}, \{Jan L\} and Machado, \{Pedro M\} and Hanna, \{Michael G\} and Lenka Plestilova and Jiri Vencovsky and \{van Engelen\}, \{Baziel G\} and Pruijn, \{Ger J M\}",

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month = feb,

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doi = "10.1136/annrheumdis-2014-206691",

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Herbert, MK, Stammen-Vogelzangs, J, Verbeek, MM, Rietveld, A, Lundberg, IE, Chinoy, H , Lamb, JA, Cooper, RG, Roberts, M, Badrising, UA, De Bleecker, JL, Machado, PM, Hanna, MG, Plestilova, L, Vencovsky, J, van Engelen, BG & Pruijn, GJM 2015, 'Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.', Annals of the rheumatic diseases, vol. 75, no. 4, pp. 696-701. https://doi.org/10.1136/annrheumdis-2014-206691

TY - JOUR

T1 - Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.

AU - Herbert, Megan K

AU - Stammen-Vogelzangs, Judith

AU - Verbeek, Marcel M

AU - Rietveld, Anke

AU - Lundberg, Ingrid E

AU - Chinoy, Hector

AU - Lamb, Janine A

AU - Cooper, Robert G

AU - Roberts, Mark

AU - Badrising, Umesh A

AU - De Bleecker, Jan L

AU - Machado, Pedro M

AU - Hanna, Michael G

AU - Plestilova, Lenka

AU - Vencovsky, Jiri

AU - van Engelen, Baziel G

AU - Pruijn, Ger J M

PY - 2015/2/24

Y1 - 2015/2/24

N2 - OBJECTIVES: The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. METHODS: Serum samples obtained from patients with IBM (n=238), PM and dermatomyositis (DM) (n=185), other autoimmune diseases (n=246), other neuromuscular diseases (n=93) and healthy controls (n=35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. RESULTS: Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37%) but not in PM, DM or non-autoimmune neuromuscular diseases (

AB - OBJECTIVES: The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. METHODS: Serum samples obtained from patients with IBM (n=238), PM and dermatomyositis (DM) (n=185), other autoimmune diseases (n=246), other neuromuscular diseases (n=93) and healthy controls (n=35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. RESULTS: Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37%) but not in PM, DM or non-autoimmune neuromuscular diseases (

KW - Autoantibodies

KW - Autoimmune Diseases

KW - Dermatomyositis

KW - Polymyositis

U2 - 10.1136/annrheumdis-2014-206691

DO - 10.1136/annrheumdis-2014-206691

M3 - Article

C2 - 25714931

SN - 1468-2060

VL - 75

SP - 696

EP - 701

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 4

ER -

Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.

Abstract

Keywords

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MMRG: Manchester Myositis Research Group

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