Disruption of the ATM gene in breast cancer

Yong Jie Lu; Alison Condie; Julie D. Bennett; Michael J. Fry; Martin R. Yuille; Janet Shipley

doi:10.1016/S0165-4608(00)00401-5

Disruption of the ATM gene in breast cancer

Yong Jie Lu, Alison Condie, Julie D. Bennett, Michael J. Fry, Martin R. Yuille, Janet Shipley

Research output: Contribution to journal › Article › peer-review

Abstract

Mutations in the ATM gene, which maps to 11q22-23, cause the multisystem recessive syndrome ataxia-telangiectasia (AT). Breast cancer has been reported in AT patients and carriers. Sporadic breast cancer is associated with loss of heterozygosity at or in the region of ATM and chromosomal abnormalities involving 11q23. We have investigated the chromosomes, nuclei and released chromatin fibers from nine primary breast carcinoma and eight cell lines by fluorescence in situ hybridization with four fluorochrome-labeled cosmids spanning the ATM gene. The ATM gene was disrupted in one primary breast carcinoma and in the cell lines MDA-MB-231 and MCF-7. The role of these aberrations in breast carcinomas, which may lead to gene dosage or dominant negative effects on gene function, requires further investigation. © 2001 Elsevier Science Inc.

Original language	English
Pages (from-to)	97-101
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	126
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(00)00401-5
Publication status	Published - 15 Apr 2001

Keywords

Ataxia Telangiectasia
Breast Neoplasms
Cell Cycle Proteins
Chromosome Aberrations
Chromosomes,Human,Pair 11
DNA-Binding Proteins
Female
genetics
Humans
In Situ Hybridization,Fluorescence
Loss of Heterozygosity
Mutation
Protein-Serine-Threonine Kinases
Proteins
Tumor Suppressor Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-4608(00)00401-5

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title = "Disruption of the ATM gene in breast cancer",

abstract = "Mutations in the ATM gene, which maps to 11q22-23, cause the multisystem recessive syndrome ataxia-telangiectasia (AT). Breast cancer has been reported in AT patients and carriers. Sporadic breast cancer is associated with loss of heterozygosity at or in the region of ATM and chromosomal abnormalities involving 11q23. We have investigated the chromosomes, nuclei and released chromatin fibers from nine primary breast carcinoma and eight cell lines by fluorescence in situ hybridization with four fluorochrome-labeled cosmids spanning the ATM gene. The ATM gene was disrupted in one primary breast carcinoma and in the cell lines MDA-MB-231 and MCF-7. The role of these aberrations in breast carcinomas, which may lead to gene dosage or dominant negative effects on gene function, requires further investigation. {\textcopyright} 2001 Elsevier Science Inc.",

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author = "Lu, {Yong Jie} and Alison Condie and Bennett, {Julie D.} and Fry, {Michael J.} and Yuille, {Martin R.} and Janet Shipley",

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AU - Lu, Yong Jie

AU - Condie, Alison

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AU - Fry, Michael J.

AU - Yuille, Martin R.

AU - Shipley, Janet

N1 - DA - 20010529IS - 0165-4608 (Print)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Cell Cycle Proteins)RN - 0 (DNA-Binding Proteins)RN - 0 (Tumor Suppressor Proteins)RN - EC 2.7.1.37 (ataxia telangiectasia mutated protein)RN - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)SB - IM

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N2 - Mutations in the ATM gene, which maps to 11q22-23, cause the multisystem recessive syndrome ataxia-telangiectasia (AT). Breast cancer has been reported in AT patients and carriers. Sporadic breast cancer is associated with loss of heterozygosity at or in the region of ATM and chromosomal abnormalities involving 11q23. We have investigated the chromosomes, nuclei and released chromatin fibers from nine primary breast carcinoma and eight cell lines by fluorescence in situ hybridization with four fluorochrome-labeled cosmids spanning the ATM gene. The ATM gene was disrupted in one primary breast carcinoma and in the cell lines MDA-MB-231 and MCF-7. The role of these aberrations in breast carcinomas, which may lead to gene dosage or dominant negative effects on gene function, requires further investigation. © 2001 Elsevier Science Inc.

AB - Mutations in the ATM gene, which maps to 11q22-23, cause the multisystem recessive syndrome ataxia-telangiectasia (AT). Breast cancer has been reported in AT patients and carriers. Sporadic breast cancer is associated with loss of heterozygosity at or in the region of ATM and chromosomal abnormalities involving 11q23. We have investigated the chromosomes, nuclei and released chromatin fibers from nine primary breast carcinoma and eight cell lines by fluorescence in situ hybridization with four fluorochrome-labeled cosmids spanning the ATM gene. The ATM gene was disrupted in one primary breast carcinoma and in the cell lines MDA-MB-231 and MCF-7. The role of these aberrations in breast carcinomas, which may lead to gene dosage or dominant negative effects on gene function, requires further investigation. © 2001 Elsevier Science Inc.

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KW - Cell Cycle Proteins

KW - Chromosome Aberrations

KW - Chromosomes,Human,Pair 11

KW - DNA-Binding Proteins

KW - Female

KW - genetics

KW - Humans

KW - In Situ Hybridization,Fluorescence

KW - Loss of Heterozygosity

KW - Mutation

KW - Protein-Serine-Threonine Kinases

KW - Proteins

KW - Tumor Suppressor Proteins

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DO - 10.1016/S0165-4608(00)00401-5

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EP - 101

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Disruption of the ATM gene in breast cancer

Abstract

Keywords

UN SDGs

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