Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.

Rogier A Kievit; Simon W Davis; Daniel J Mitchell; Jason R Taylor; John Duncan; Richard N A Henson; Lorraine K Tyler; Carol Brayne; Ed Bullmore; Andrew Calder; Rhodri Cusack; Tim Dalgleish; Fiona Matthews; William Marslen-Wilson; James Rowe; Meredith Shafto; Karen Campbell; Teresa Cheung; Linda Geerligs; Anna McCarrey; Kamen Tsvetanov; Nitin Williams; Lauren Bates; Tina Emery; Sharon Erzinçlioglu; Andrew Gadie; Sofia Gerbase; Stanimira Georgieva; Claire Hanley; Beth Parkin; David Troy; Jodie Allen; Gillian Amery; Liana Amunts; Anne Barcroft; Amanda Castle; Cheryl Dias; Jonathan Dowrick; Melissa Fair; Hayley Fisher; Anna Goulding; Adarsh Grewal; Geoff Hale; Andrew Hilton; Frances Johnson; Patricia Johnston; Thea Kavanagh-Williamson; Magdalena Kwasniewska; Alison McMinn; Kim Norman; Jessica Penrose; Fiona Roby; Diane Rowland; John Sargeant; Maggie Squire; Beth Stevens; Aldabra Stoddart; Cheryl Stone; Tracy Thompson; Ozlem Yazlik; Dan Barnes; Marie Dixon; Jaya Hillman; Joanne Mitchell; Laura Villis

doi:10.1038/ncomms6658

Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.

Rogier A Kievit, Simon W Davis, Daniel J Mitchell, Jason R Taylor, John Duncan, Richard N A Henson, Lorraine K Tyler (Collaborator), Carol Brayne (Collaborator), Ed Bullmore (Collaborator), Andrew Calder (Collaborator), Rhodri Cusack (Collaborator), Tim Dalgleish (Collaborator), Fiona Matthews (Collaborator), William Marslen-Wilson (Collaborator), James Rowe (Collaborator), Meredith Shafto (Collaborator), Karen Campbell (Collaborator), Teresa Cheung (Collaborator), Linda Geerligs (Collaborator), Anna McCarrey (Collaborator)Kamen Tsvetanov (Collaborator), Nitin Williams (Collaborator), Lauren Bates (Collaborator), Tina Emery (Collaborator), Sharon Erzinçlioglu (Collaborator), Andrew Gadie (Collaborator), Sofia Gerbase (Collaborator), Stanimira Georgieva (Collaborator), Claire Hanley (Collaborator), Beth Parkin (Collaborator), David Troy (Collaborator), Jodie Allen (Collaborator), Gillian Amery (Collaborator), Liana Amunts (Collaborator), Anne Barcroft (Collaborator), Amanda Castle (Collaborator), Cheryl Dias (Collaborator), Jonathan Dowrick (Collaborator), Melissa Fair (Collaborator), Hayley Fisher (Collaborator), Anna Goulding (Collaborator), Adarsh Grewal (Collaborator), Geoff Hale (Collaborator), Andrew Hilton (Collaborator), Frances Johnson (Collaborator), Patricia Johnston (Collaborator), Thea Kavanagh-Williamson (Collaborator), Magdalena Kwasniewska (Collaborator), Alison McMinn (Collaborator), Kim Norman (Collaborator), Jessica Penrose (Collaborator), Fiona Roby (Collaborator), Diane Rowland (Collaborator), John Sargeant (Collaborator), Maggie Squire (Collaborator), Beth Stevens (Collaborator), Aldabra Stoddart (Collaborator), Cheryl Stone (Collaborator), Tracy Thompson (Collaborator), Ozlem Yazlik (Collaborator), Dan Barnes (Collaborator), Marie Dixon (Collaborator), Jaya Hillman (Collaborator), Joanne Mitchell (Collaborator), Laura Villis (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal cortex. However, age-related changes are likely multifactorial, and the relationship between neural changes and cognitive measures is not well-understood. Here we address this in a large (N=567), population-based sample drawn from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data. We relate fluid intelligence and multitasking to multiple brain measures, including grey matter in various prefrontal regions and white matter integrity connecting those regions. We show that multitasking and fluid intelligence are separable cognitive abilities, with differential sensitivities to age, which are mediated by distinct neural subsystems that show different prediction in older versus younger individuals. These results suggest that prefrontal ageing is a manifold process demanding multifaceted models of neurocognitive ageing.

Original language	English
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms6658
Publication status	Published - 2014

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10.1038/ncomms6658

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Kievit, R. A., Davis, S. W., Mitchell, D. J., Taylor, J. R., Duncan, J., Henson, R. N. A., Tyler, L. K., Brayne, C., Bullmore, E., Calder, A., Cusack, R., Dalgleish, T., Matthews, F., Marslen-Wilson, W., Rowe, J., Shafto, M., Campbell, K., Cheung, T., Geerligs, L., ... Villis, L. (2014). Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking. Nature Communications, 5. https://doi.org/10.1038/ncomms6658

@article{79bc304c66f740c88d699d663ea1dcd5,

title = "Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.",

abstract = "Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal cortex. However, age-related changes are likely multifactorial, and the relationship between neural changes and cognitive measures is not well-understood. Here we address this in a large (N=567), population-based sample drawn from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data. We relate fluid intelligence and multitasking to multiple brain measures, including grey matter in various prefrontal regions and white matter integrity connecting those regions. We show that multitasking and fluid intelligence are separable cognitive abilities, with differential sensitivities to age, which are mediated by distinct neural subsystems that show different prediction in older versus younger individuals. These results suggest that prefrontal ageing is a manifold process demanding multifaceted models of neurocognitive ageing.",

author = "Kievit, {Rogier A} and Davis, {Simon W} and Mitchell, {Daniel J} and Taylor, {Jason R} and John Duncan and Henson, {Richard N A} and Tyler, {Lorraine K} and Carol Brayne and Ed Bullmore and Andrew Calder and Rhodri Cusack and Tim Dalgleish and Fiona Matthews and William Marslen-Wilson and James Rowe and Meredith Shafto and Karen Campbell and Teresa Cheung and Linda Geerligs and Anna McCarrey and Kamen Tsvetanov and Nitin Williams and Lauren Bates and Tina Emery and Sharon Erzin{\c c}lioglu and Andrew Gadie and Sofia Gerbase and Stanimira Georgieva and Claire Hanley and Beth Parkin and David Troy and Jodie Allen and Gillian Amery and Liana Amunts and Anne Barcroft and Amanda Castle and Cheryl Dias and Jonathan Dowrick and Melissa Fair and Hayley Fisher and Anna Goulding and Adarsh Grewal and Geoff Hale and Andrew Hilton and Frances Johnson and Patricia Johnston and Thea Kavanagh-Williamson and Magdalena Kwasniewska and Alison McMinn and Kim Norman and Jessica Penrose and Fiona Roby and Diane Rowland and John Sargeant and Maggie Squire and Beth Stevens and Aldabra Stoddart and Cheryl Stone and Tracy Thompson and Ozlem Yazlik and Dan Barnes and Marie Dixon and Jaya Hillman and Joanne Mitchell and Laura Villis",

year = "2014",

doi = "10.1038/ncomms6658",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

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Kievit, RA, Davis, SW, Mitchell, DJ, Taylor, JR, Duncan, J, Henson, RNA, Tyler, LK, Brayne, C, Bullmore, E, Calder, A, Cusack, R, Dalgleish, T, Matthews, F, Marslen-Wilson, W, Rowe, J, Shafto, M, Campbell, K, Cheung, T, Geerligs, L, McCarrey, A, Tsvetanov, K, Williams, N, Bates, L, Emery, T, Erzinçlioglu, S, Gadie, A, Gerbase, S, Georgieva, S, Hanley, C, Parkin, B, Troy, D, Allen, J, Amery, G, Amunts, L, Barcroft, A, Castle, A, Dias, C, Dowrick, J, Fair, M, Fisher, H, Goulding, A, Grewal, A, Hale, G, Hilton, A, Johnson, F, Johnston, P, Kavanagh-Williamson, T, Kwasniewska, M, McMinn, A, Norman, K, Penrose, J, Roby, F, Rowland, D, Sargeant, J, Squire, M, Stevens, B, Stoddart, A, Stone, C, Thompson, T, Yazlik, O, Barnes, D, Dixon, M, Hillman, J, Mitchell, J & Villis, L 2014, 'Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.', Nature Communications, vol. 5. https://doi.org/10.1038/ncomms6658

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T1 - Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.

AU - Kievit, Rogier A

AU - Davis, Simon W

AU - Mitchell, Daniel J

AU - Taylor, Jason R

AU - Duncan, John

AU - Henson, Richard N A

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A2 - Brayne, Carol

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A2 - Rowe, James

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A2 - Tsvetanov, Kamen

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A2 - Troy, David

A2 - Allen, Jodie

A2 - Amery, Gillian

A2 - Amunts, Liana

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A2 - Castle, Amanda

A2 - Dias, Cheryl

A2 - Dowrick, Jonathan

A2 - Fair, Melissa

A2 - Fisher, Hayley

A2 - Goulding, Anna

A2 - Grewal, Adarsh

A2 - Hale, Geoff

A2 - Hilton, Andrew

A2 - Johnson, Frances

A2 - Johnston, Patricia

A2 - Kavanagh-Williamson, Thea

A2 - Kwasniewska, Magdalena

A2 - McMinn, Alison

A2 - Norman, Kim

A2 - Penrose, Jessica

A2 - Roby, Fiona

A2 - Rowland, Diane

A2 - Sargeant, John

A2 - Squire, Maggie

A2 - Stevens, Beth

A2 - Stoddart, Aldabra

A2 - Stone, Cheryl

A2 - Thompson, Tracy

A2 - Yazlik, Ozlem

A2 - Barnes, Dan

A2 - Dixon, Marie

A2 - Hillman, Jaya

A2 - Mitchell, Joanne

A2 - Villis, Laura

PY - 2014

Y1 - 2014

N2 - Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal cortex. However, age-related changes are likely multifactorial, and the relationship between neural changes and cognitive measures is not well-understood. Here we address this in a large (N=567), population-based sample drawn from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data. We relate fluid intelligence and multitasking to multiple brain measures, including grey matter in various prefrontal regions and white matter integrity connecting those regions. We show that multitasking and fluid intelligence are separable cognitive abilities, with differential sensitivities to age, which are mediated by distinct neural subsystems that show different prediction in older versus younger individuals. These results suggest that prefrontal ageing is a manifold process demanding multifaceted models of neurocognitive ageing.

AB - Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal cortex. However, age-related changes are likely multifactorial, and the relationship between neural changes and cognitive measures is not well-understood. Here we address this in a large (N=567), population-based sample drawn from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data. We relate fluid intelligence and multitasking to multiple brain measures, including grey matter in various prefrontal regions and white matter integrity connecting those regions. We show that multitasking and fluid intelligence are separable cognitive abilities, with differential sensitivities to age, which are mediated by distinct neural subsystems that show different prediction in older versus younger individuals. These results suggest that prefrontal ageing is a manifold process demanding multifaceted models of neurocognitive ageing.

U2 - 10.1038/ncomms6658

DO - 10.1038/ncomms6658

M3 - Article

C2 - 25519467

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

ER -

Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.

Abstract

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