Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo

Georgia Perona-Wright, Stephen J. Jenkins, Alison Crawford, David Gray, Edward J. Pearce, Andrew S. MacDonald

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Dendritic cells (DC) can both initiate an immune response and dictate its character. Cytokines are critically involved in this process and, although interleukin (IL)-10 is known as a potent immunosuppressant, the impact of its release from DC remains unclear. Here, we transfer pathogen-conditioned murine DC in vivo and show that, while DC-derived IL-10 can act to limit Th1 development, it is not required for Th2 induction. In both Th2 and Th1 settings, however, IL-10 from cells other than the initiating DC dominates the regulation of the emerging effector cell populations. Surprisingly, the critical source of IL-10 in this process is neither T nor B cells. These data illustrate the distinct actions of IL-10 during differently polarised, pathogen-focussed, DC-driven immune responses in vivo. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)2367-2375
    Number of pages8
    JournalEuropean journal of immunology
    Volume36
    Issue number9
    DOIs
    Publication statusPublished - Sept 2006

    Keywords

    • Bacteria
    • Cytokines
    • Dendritic cells
    • Helminths
    • Th1/Th2 cells

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