Dna Damage and Repair

E.M. Hammond; I.M. Pires; A.J. Giaccia

doi:10.1016/B978-1-4160-5897-7.00002-0

Dna Damage and Repair

E.M. Hammond, I.M. Pires, A.J. Giaccia

Division of Cancer Sciences (L5)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity. Five major pathways exist to repair specific types of DNA damage: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), nonhomologous end joining (NHEJ), and homologous recombination (HR). We discuss each of these in turn, and include an overview of the pathways and highlight the human syndromes or cancers caused by abrogation of the pathways.

Original language	English
Title of host publication	Leibel and Phillips Textbook of Radiation Oncology
Editors	Richard T. Hoppe, Mack Roach, Theodore Locke Phillips
Place of Publication	Philadelphia, PA
Publisher	Elsevier BV
Chapter	2
Pages	31-39
Number of pages	9
Edition	3rd
ISBN (Print)	9781416058977
DOIs	https://doi.org/10.1016/B978-1-4160-5897-7.00002-0
Publication status	Published - 2010

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10.1016/B978-1-4160-5897-7.00002-0

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title = "Dna Damage and Repair",

abstract = "Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity. Five major pathways exist to repair specific types of DNA damage: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), nonhomologous end joining (NHEJ), and homologous recombination (HR). We discuss each of these in turn, and include an overview of the pathways and highlight the human syndromes or cancers caused by abrogation of the pathways.",

author = "E.M. Hammond and I.M. Pires and A.J. Giaccia",

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T1 - Dna Damage and Repair

AU - Hammond, E.M.

AU - Pires, I.M.

AU - Giaccia, A.J.

PY - 2010

Y1 - 2010

N2 - Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity. Five major pathways exist to repair specific types of DNA damage: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), nonhomologous end joining (NHEJ), and homologous recombination (HR). We discuss each of these in turn, and include an overview of the pathways and highlight the human syndromes or cancers caused by abrogation of the pathways.

AB - Our aim in this chapter is to highlight the biologic effort expended by a cell in protecting its deoxyribonucleic acid (DNA). Cellular DNA is under constant attack from both exogenous and endogenous agents and it is crucial that DNA damage is repaired efficiently and with fidelity to maintain genomic integrity. Five major pathways exist to repair specific types of DNA damage: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), nonhomologous end joining (NHEJ), and homologous recombination (HR). We discuss each of these in turn, and include an overview of the pathways and highlight the human syndromes or cancers caused by abrogation of the pathways.

U2 - 10.1016/B978-1-4160-5897-7.00002-0

DO - 10.1016/B978-1-4160-5897-7.00002-0

M3 - Chapter

SN - 9781416058977

SP - 31

EP - 39

BT - Leibel and Phillips Textbook of Radiation Oncology

A2 - Hoppe, Richard T.

A2 - Roach, Mack

A2 - Locke Phillips, Theodore

PB - Elsevier BV

CY - Philadelphia, PA

ER -

Dna Damage and Repair

Abstract

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