DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

Jin Hwa Lee, Gary M Hunninghake, James D Crapo (Collaborator), Elizabeth Regan (Collaborator), Stephanie Bratschie (Collaborator), Rochelle Lantz (Collaborator), Sandra Melanson (Collaborator), Lori Stepp (Collaborator), Terri Beaty (Collaborator), Douglas Everett (Collaborator), David Lynch (Collaborator), E Sutherland (Collaborator), Eugene R Bleecker (Collaborator), Ronald G Crystal (Collaborator), James C Hogg (Collaborator), Michael A Province (Collaborator), Duncan C Thomas (Collaborator), Thomas Croxton (Collaborator), Weiniu Gan (Collaborator), Lisa Postow (Collaborator)John W Walsh (Collaborator), Randel Plant (Collaborator), Delia Prieto (Collaborator), Andre Williams (Collaborator), Ruthie Knowles (Collaborator), Carla Wilson (Collaborator), John Hokanson (Collaborator), Jennifer Black-shinn (Collaborator), Gregory Kinney (Collaborator), Peter J Castaldi (Collaborator), Michael Cho (Collaborator), Megan E Hardin (Collaborator), Craig Hersh (Collaborator), Nan Laird (Collaborator), Sharon M Lutz (Collaborator), Manuel Mattheisen (Collaborator), Merry-Lynn McDonald (Collaborator), Margaret M Parker (Collaborator), Elizabeth A Regan (Collaborator), Stephanie Santorico (Collaborator), Emily S Wan (Collaborator), Jin Zhou (Collaborator), Mustafa Al Qaisi (Collaborator), Jaleh Akhavan (Collaborator), Christian W Cox (Collaborator), Deanna Cusick (Collaborator), Jennifer G Dy (Collaborator), Shoshana Ginsburg (Collaborator), Eric A Hoffman (Collaborator), Philip F Judy (Collaborator), Alex Kluiber (Collaborator), Alexander McKenzie (Collaborator), John J Reilly (Collaborator), James Ross (Collaborator), Raul San Jose Estepar (Collaborator), Jered Sieren (Collaborator), Arkadiusz Sitek (Collaborator), Douglas Stinson (Collaborator), Edwin van Beek (Collaborator), Jordan Zach (Collaborator), Robert Jensen (Collaborator), Homayoon Farzadegan (Collaborator), Samantha Bragan (Collaborator), Stacey Cayetano (Collaborator), Jeffrey Curtis (Collaborator), Ella Kazerooni (Collaborator), Nicola Hanania (Collaborator), Philip Alapat (Collaborator), Venkata Bandi (Collaborator), Kalpalatha Guntupalli (Collaborator), Elizabeth Guy (Collaborator), Antara Mallampalli (Collaborator), Charles Trinh (Collaborator), Mustafa Atik (Collaborator), Hasan Al-Azzawi (Collaborator), Marc Willis (Collaborator), Susan Pinero (Collaborator), Linda Fahr (Collaborator), Arun Nachiappan (Collaborator), Collin Bray (Collaborator), L Frigini (Collaborator), Carlos Farinas (Collaborator), David Katz (Collaborator), Jose Freytes (Collaborator), Dawn DeMeo (Collaborator), George Washko (Collaborator), Francine Jacobson (Collaborator), Hiroto Hatabu (Collaborator), Peter Clarke (Collaborator), Ritu Gill (Collaborator), Andetta Hunsaker (Collaborator), Beatrice Trotman-Dickenson (Collaborator), Rachna Madan (Collaborator), R Barr (Collaborator), Byron Thomashow (Collaborator), John Austin (Collaborator), Belinda D'Souza (Collaborator), H McAdams (Collaborator), Richard Rosiello (Collaborator), Timothy Bresnahan (Collaborator), Joseph Bradley (Collaborator), Steven Meller (Collaborator), Suzanne Roland (Collaborator), Charlene McEvoy (Collaborator), Joseph Tashjian (Collaborator), Nadia Hansel (Collaborator), Robert Brown (Collaborator), Gregory Diette (Collaborator), Karen Horton (Collaborator), Janos PORSZASZ (Collaborator), Hans Fischer (Collaborator), Matt Budoff (Collaborator), Mehdi Rambod (Collaborator), Michael E DeBakey (Collaborator), Hirani Kamal (Collaborator), Roham Darvishi (Collaborator), Dennis Niewoehner (Collaborator), Quentin Anderson (Collaborator), Kathryn Rice (Collaborator), Audrey Caine (Collaborator), Marilyn Foreman (Collaborator), Eugene Berkowitz (Collaborator), Russell Bowler (Collaborator), Joyce Schroeder (Collaborator), Valerie Hale (Collaborator), John Armstrong (Collaborator), Jonathan Chung (Collaborator), Gerard Criner (Collaborator), Victor Kim (Collaborator), Nathaniel Marchetti (Collaborator), Aditi Satti (Collaborator), A Mamary (Collaborator), Robert Steiner (Collaborator), Chandra Dass (Collaborator), Libby Cone (Collaborator), William Bailey (Collaborator), Mark Dransfield (Collaborator), Michael Wells (Collaborator), Surya Bhatt (Collaborator), Hrudaya Nath (Collaborator), Satinder Singh (Collaborator), Joe Ramsdell (Collaborator), Paul Friedman (Collaborator), Alejandro Cornellas (Collaborator), John Newell (Collaborator), Edwin J R van Beek (Collaborator), Fernando Martinez (Collaborator), Meilan Han (Collaborator), Christine Wendt (Collaborator), Tadashi Allen (Collaborator), Joel Weissfeld (Collaborator), Carl Fuhrman (Collaborator), Jessica Bon (Collaborator), Danielle Hooper (Collaborator), Sandra Adams (Collaborator), Carlos Orozco (Collaborator), Mario Ruiz (Collaborator), Amy Mumbower (Collaborator), Ariel Kruger (Collaborator), Carlos Restrepo (Collaborator), Michael Lane (Collaborator), Y Ivanov (Collaborator), K Kostov (Collaborator), J Bourbeau (Collaborator), M Fitzgerald (Collaborator), P Hernandez (Collaborator), K Killian (Collaborator), R Levy (Collaborator), F Maltais (Collaborator), J Krepelka (Collaborator), E Wouters (Collaborator), D Quinn (Collaborator), P Bakke (Collaborator), M Kosnik (Collaborator), A Agusti (Collaborator), J Sauleda (Collaborator), Y Feschenko (Collaborator), V Gavrisyuk (Collaborator), L Yashina (Collaborator), N Monogarova (Collaborator), P Calverley (Collaborator), D Lomas (Collaborator), W MacNee (Collaborator), D Singh (Collaborator), J Wedzicha (Collaborator), A Anzueto (Collaborator), S Braman (Collaborator), R Casaburi (Collaborator), B Celli (Collaborator), G Giessel (Collaborator), M Gotfried (Collaborator), G Greenwald (Collaborator), D Mahler (Collaborator), B Make (Collaborator), S Rennard (Collaborator), C Rochester (Collaborator), P Scanlon (Collaborator), F Sciurba (Collaborator), A Sharafkhaneh (Collaborator), T Siler (Collaborator), E Silverman (Collaborator), A Wanner (Collaborator), R Wise (Collaborator), H Coxson (Collaborator), C Crim (Collaborator), J Vestbo (Collaborator), J Yates (Collaborator), B Miller (Collaborator), R Tal-Singer (Collaborator)

    Research output: Contribution to journalArticlepeer-review


    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total lung capacity (TLC) is an indicator of hyperinflation particularly in subjects with moderate-to-severe airflow obstruction. The aim of our study was to identify genetic variants associated with TLC in COPD. METHODS: We performed genome-wide association studies (GWASs) in white subjects from three cohorts: the COPDGene Study; the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE); and GenKOLS (Bergen, Norway). All subjects were current or ex-smokers with at least moderate airflow obstruction, defined by a ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC)
    Original languageEnglish
    JournalRespiratory research
    Publication statusPublished - 2014


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