Intracellular metabolites and pH (pH(i)) were measured in isolated ferret hearts, using nuclear magnetic resonance spectroscopy. Cyanide decreased, developed pressure and produced an intracellular acidosis. However, removing this acidosis did not restore contraction. This shows that a pH-independent effect (possibly an increase of inorganic phosphate) may be responsible for the CN-induced decrease of pressure.
|Number of pages||2|
|Publication status||Published - 1988|