Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia?

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Intracellular metabolites and pH (pH(i)) were measured in isolated ferret hearts, using nuclear magnetic resonance spectroscopy. Cyanide decreased, developed pressure and produced an intracellular acidosis. However, removing this acidosis did not restore contraction. This shows that a pH-independent effect (possibly an increase of inorganic phosphate) may be responsible for the CN-induced decrease of pressure.
    Original languageEnglish
    Pages (from-to)143-145
    Number of pages2
    JournalBiomedical Research
    Volume9
    Issue number2
    Publication statusPublished - 1988

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