Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia?

D. A. Eisner; A. C. Elliott; G. L. Smith

Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia?

D. A. Eisner, A. C. Elliott, G. L. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

Intracellular metabolites and pH (pH(i)) were measured in isolated ferret hearts, using nuclear magnetic resonance spectroscopy. Cyanide decreased, developed pressure and produced an intracellular acidosis. However, removing this acidosis did not restore contraction. This shows that a pH-independent effect (possibly an increase of inorganic phosphate) may be responsible for the CN-induced decrease of pressure.

Original language	English
Pages (from-to)	143-145
Number of pages	2
Journal	Biomedical Research
Volume	9
Issue number	2
Publication status	Published - 1988

Cite this

@article{2339b0b8a0b84d38bc076ad6cfb8af92,

title = "Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia?",

abstract = "Intracellular metabolites and pH (pH(i)) were measured in isolated ferret hearts, using nuclear magnetic resonance spectroscopy. Cyanide decreased, developed pressure and produced an intracellular acidosis. However, removing this acidosis did not restore contraction. This shows that a pH-independent effect (possibly an increase of inorganic phosphate) may be responsible for the CN-induced decrease of pressure.",

author = "Eisner, {D. A.} and Elliott, {A. C.} and Smith, {G. L.}",

year = "1988",

language = "English",

volume = "9",

pages = "143--145",

journal = "Biomedical Research",

issn = "1880-313X",