Do demographics and tumour-related factors affect nodal yield at neck dissection?:  A retrospective cohort study

R Lim; L Evans; A George; N de Alwis; P Stimpson; Samuel W D Merriel; C Giddings; B. Billah; J. A. Smith; Adnan Safdar; Elizabeth Sigston

doi:10.1017/s0022215116009208

Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study

R Lim, L Evans, A George, N de Alwis, P Stimpson, Samuel W D Merriel, C Giddings, B. Billah, J. A. Smith, Adnan Safdar, Elizabeth Sigston

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background:
Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.

Method:
A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.

Results:
The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.

Conclusion:
In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

Original language	English
Pages (from-to)	S36-S40
Number of pages	5
Journal	The Journal of laryngology and otology
Volume	131
Issue number	S1
Early online date	27 Oct 2016
DOIs	https://doi.org/10.1017/s0022215116009208
Publication status	Published - 1 Jan 2017

Keywords

squamous cell carcinoma
neck dissection
P16 protein, human
age of onset
gender
body mass index

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/s0022215116009208

Cite this

@article{17f769a873004dab940e11762e918f0f,

title = "Do demographics and tumour-related factors affect nodal yield at neck dissection?: A retrospective cohort study",

abstract = "Background:Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.Method:A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.Results:The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.Conclusion:In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.",

keywords = "squamous cell carcinoma, neck dissection, P16 protein, human, age of onset, gender, body mass index",

author = "R Lim and L Evans and A George and Alwis, {N de} and P Stimpson and Merriel, {Samuel W D} and C Giddings and B. Billah and Smith, {J. A.} and Adnan Safdar and Elizabeth Sigston",

year = "2017",

month = jan,

day = "1",

doi = "10.1017/s0022215116009208",

language = "English",

volume = "131",

pages = "S36--S40",

journal = "The Journal of laryngology and otology",

issn = "0022-2151",

publisher = "Cambridge University Press",

number = "S1",

}

TY - JOUR

T1 - Do demographics and tumour-related factors affect nodal yield at neck dissection?

T2 - A retrospective cohort study

AU - Lim, R

AU - Evans, L

AU - George, A

AU - Alwis, N de

AU - Stimpson, P

AU - Merriel, Samuel W D

AU - Giddings, C

AU - Billah, B.

AU - Smith, J. A.

AU - Safdar, Adnan

AU - Sigston, Elizabeth

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background:Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.Method:A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.Results:The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.Conclusion:In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

AB - Background:Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.Method:A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.Results:The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.Conclusion:In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

KW - squamous cell carcinoma

KW - neck dissection

KW - P16 protein, human

KW - age of onset

KW - gender

KW - body mass index

UR - http://europepmc.org/abstract/med/27786150

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DO - 10.1017/s0022215116009208

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SN - 0022-2151

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JO - The Journal of laryngology and otology

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