Abstract
Background: Biliary tract cancers (BTCs) include cholangiocarcinoma, which refers to cancers arising in the intrahepatic, perihilar or distal biliary tree, ampulla of vater and gallbladder carcinoma. Even after complete surgical resection, a large number of BTC patients develop recurrence. Whether recurrence after surgery and de novo metastatic BTC should have comparable stratification in first-line palliative systemic therapy clinical studies is unknown.Methods: 480 patients who received palliative chemotherapy as first-line treatment for advanced BTC between January 1987 and May 2014 in Princess Margaret Cancer Centre, Toronto were reviewed. Probability of overall survival (OS) was estimated using the Kaplan-Meier method, and independent prognostic factors for OS were identified using the multivariable Cox proportional hazard model. Results: There were 171 recurrent and 309 de novo metastatic patients. Median age at diagnosis was 62 years, performance status
| Original language | English |
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| Pages | NA-NA |
| Publication status | Published - 15 Jan 2015 |
| Event | 2015 Gastrointestinal Cancers Symposium - San Francisco Duration: 15 Jan 2015 → 17 Jan 2015 |
Conference
| Conference | 2015 Gastrointestinal Cancers Symposium |
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| City | San Francisco |
| Period | 15/01/15 → 17/01/15 |
Keywords
- Biliary tract cancer
- Recurrence
- De novo metastatic
- outcome
