Docking domains and substrate-specificity determination for MAP kinases

Andrew D. Sharrocks, Shen His Yang, Alex Galanis

    Research output: Contribution to journalArticlepeer-review


    Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.
    Original languageEnglish
    Pages (from-to)448-453
    Number of pages5
    JournalTrends in Biochemical Sciences
    Issue number9
    Publication statusPublished - 1 Sep 2000


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