Docking domains and substrate-specificity determination for MAP kinases

Andrew D. Sharrocks; Shen His Yang; Alex Galanis

doi:10.1016/S0968-0004(00)01627-3

Docking domains and substrate-specificity determination for MAP kinases

Andrew D. Sharrocks, Shen His Yang, Alex Galanis

Research output: Contribution to journal › Article › peer-review

Abstract

Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	448-453
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/S0968-0004(00)01627-3
Publication status	Published - 1 Sept 2000

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title = "Docking domains and substrate-specificity determination for MAP kinases",

abstract = "Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.",

author = "Sharrocks, {Andrew D.} and Yang, {Shen His} and Alex Galanis",

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AU - Yang, Shen His

AU - Galanis, Alex

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N2 - Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.

AB - Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.

U2 - 10.1016/S0968-0004(00)01627-3

DO - 10.1016/S0968-0004(00)01627-3

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VL - 25

SP - 448

EP - 453

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 9

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Docking domains and substrate-specificity determination for MAP kinases

Abstract

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