Abstract
Purpose: To show how naïve analyses of aggregated UK ART Register data held by the Human Fertilisation and Embryology Authority to estimate the effects of PGT-A can be severely misleading and to indicate how it may be possible to do a more credible analysis. Given the limitations of the Register, we consider the extent to which such an analysis has the potential to answer questions about the real-world effectiveness of PGT-A. Methods: We utilise the publicly available Register datasets and construct logistic regression models for live birth events (LBE) which adjust for confounding. We compare all PGT-A cycles to control groups of cycles that could have had PGT-A, excluding cycles that did not progress to having embryos for biopsy. Results: The primary model gives an odds ratio for LBE of 0.82 (95% CI 0.68–1.00) suggesting PGT-A may be detrimental rather than beneficial. However, due to limitations in the availability of important variables in the public dataset, this cannot be considered a definitive estimate. We outline the steps required to enable a credible analysis of the Register data. Conclusion: If we compare like with like groups, we obtain estimates of the effect of PGT-A that suggest an overall modest reduction in treatment success rates. These are in direct contrast to an invalid comparison of crude success rates. A detailed analysis of a fuller dataset is warranted, but it remains to be demonstrated whether the UK Register data can provide useful estimates of the impact of PGT-A when used as a treatment add-on.
Original language | English |
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Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | Journal of Assisted Reproduction and Genetics |
Early online date | 21 Sept 2022 |
DOIs | |
Publication status | Published - 21 Sept 2022 |
Keywords
- Assisted Reproduction
- Live birth rates
- Preimplantation genetic testing aneuploidy
- Registry data
- Retrospective study