TY - JOUR
T1 - Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants?
AU - Papadopoulos, Nikolaos G.
AU - Gourgiotis, Dimitrios
AU - Javadyan, Artem
AU - Bossios, Apostolos
AU - Kallergi, Konstantina
AU - Psarras, Stelios
AU - Tsolia, Maria N.
AU - Kafetzis, Dimitrios
PY - 2004/9
Y1 - 2004/9
N2 - Respiratory syncytial virus (RSV) subtypes A and B are present either simultaneously or alternate during yearly epidemics. It is still not clear whether clinical severity of acute bronchiolitis differs between the two subtypes. Reverse transcription polymerase chain reaction was used to subtype RSV in previously healthy infants hospitalized with RSV bronchiolitis during a winter epidemic. A severity index based on heart rate, respiratory rate, wheezing, difficulty in feeding and oxygen saturation was calculated upon admission.Infants infected with RSV subtype-A were found to have a significantly higher (more severe) clinical score than those infected with RSV-B. There was no statistically significant difference in duration of hospitalization or need of intensive care. Boys and infants younger than 3 months of age were also more severely affected than girls or older infants, respectively.These results support the notion that RSV-A-induced bronchiolitis is more severe than RSV-B-induced one, in agreement with the majority of previously published studies. © 2004 Elsevier Ltd. All rights reserved.
AB - Respiratory syncytial virus (RSV) subtypes A and B are present either simultaneously or alternate during yearly epidemics. It is still not clear whether clinical severity of acute bronchiolitis differs between the two subtypes. Reverse transcription polymerase chain reaction was used to subtype RSV in previously healthy infants hospitalized with RSV bronchiolitis during a winter epidemic. A severity index based on heart rate, respiratory rate, wheezing, difficulty in feeding and oxygen saturation was calculated upon admission.Infants infected with RSV subtype-A were found to have a significantly higher (more severe) clinical score than those infected with RSV-B. There was no statistically significant difference in duration of hospitalization or need of intensive care. Boys and infants younger than 3 months of age were also more severely affected than girls or older infants, respectively.These results support the notion that RSV-A-induced bronchiolitis is more severe than RSV-B-induced one, in agreement with the majority of previously published studies. © 2004 Elsevier Ltd. All rights reserved.
KW - Respiratory infections
KW - RSV
KW - Severity
KW - Subgroup
U2 - 10.1016/j.rmed.2004.01.009
DO - 10.1016/j.rmed.2004.01.009
M3 - Article
C2 - 15338801
SN - 0954-6111
VL - 98
SP - 879
EP - 882
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 9
ER -