Does the measurement of serum fructosamine accurately reflect levels of glycated albumin in insulin-dependent diabetes?

P. H. Winocour, D. Bhatnagar, P. Reed, H. Dhar

Research output: Contribution to journalArticlepeer-review

Abstract

We have measured serum glycated albumin (GSA) by affinity chromatography and immunoturbidimetry, and serum fructosamine using a Cobas FARA analyser in blood samples from 37 type I diabetics and 21 healthy controls. Random blood glucose and glycated haemoglobin levels were also measured. Glycated haemoglobin (HbA1) correlated with glycated albumin and fructosamine in the diabetic group. A less clear relationship was found between glycated albumin and fructosamine. HbA1, GSA and fructosamine correlated poorly with random blood glucose levels. These data indicate that serum fructosamine levels do not accurately reflect those of glycated albumin, as has recently been suggested, in type I insulin-dependent diabetics where glycaemic control fluctuates more than in type II diabetics. It is postulated that the two methods reflect varying glycaemic levels to a different degree, thereby accounting for the disparity.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalAnnals of Clinical Biochemistry
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Jan 1987

Keywords

  • fructosamine
  • blood and hemopoietic system
  • diagnosis
  • endocrine system
  • human
  • human cell
  • insulin dependent diabetes mellitus
  • priority journal
  • serum

Research Beacons, Institutes and Platforms

  • Global Development Institute

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