Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts

Christopher Teskey; Shariar Md Abu Sohel; Danielle Bunting; Sachinkumar Modha; Michael Greaney

doi:10.1002/anie.201701523

Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts

Christopher Teskey
, Shariar Md Abu Sohel
, Danielle Bunting
, Sachinkumar Modha
, Michael Greaney

Research output: Contribution to journal › Article › peer-review

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Abstract

Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

Original language	English
Pages (from-to)	5263–5266
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	19
Early online date	7 Apr 2017
DOIs	https://doi.org/10.1002/anie.201701523
Publication status	Published - 2017

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title = "Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts",

abstract = "Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.",

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AU - Teskey, Christopher

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AU - Modha, Sachinkumar

AU - Greaney, Michael

PY - 2017

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N2 - Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

AB - Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

U2 - 10.1002/anie.201701523

DO - 10.1002/anie.201701523

M3 - Article

SN - 1433-7851

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SP - 5263

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts

Abstract

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