TY - JOUR
T1 - Don’t sugar coat it: the effects of gestational diabetes on the placental vasculature
AU - Byford, Abigail
AU - Baird-Rayner, Chloe
AU - Forbes, Karen
PY - 2021/4/6
Y1 - 2021/4/6
N2 - The placenta is a temporary organ, which facilitates the exchange of nutrients, waste and gases between the maternal and fetal circulatory systems. To perform its role, the placenta is a villous structure, which branches to cover a large surface area. In gestational diabetes (GDM), a major complication that affects otherwise healthy pregnancies, the placenta displays aberrant vasculature, including altered vascularization, villous immaturity, and endothelial dysfunction. Several contributors including reactive oxygen species (ROS), advanced glycation end products (AGEs) and the dysregulation of key angiogenic factors have been attributed to vascular dysfunction in GDM.
AB - The placenta is a temporary organ, which facilitates the exchange of nutrients, waste and gases between the maternal and fetal circulatory systems. To perform its role, the placenta is a villous structure, which branches to cover a large surface area. In gestational diabetes (GDM), a major complication that affects otherwise healthy pregnancies, the placenta displays aberrant vasculature, including altered vascularization, villous immaturity, and endothelial dysfunction. Several contributors including reactive oxygen species (ROS), advanced glycation end products (AGEs) and the dysregulation of key angiogenic factors have been attributed to vascular dysfunction in GDM.
UR - https://www.scopus.com/pages/publications/85104813898
U2 - 10.1042/bio_2021_117
DO - 10.1042/bio_2021_117
M3 - Review article
SN - 1740-1194
VL - 43
SP - 34
EP - 39
JO - The Biochemist
JF - The Biochemist
IS - 2
ER -
