Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilic heterocycle

Heloise Brice, Jonathan Clayden

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Isonicotinamides carrying N-furanylmethyl, N-pyrrolylalkyl or N-thiophenylmethyl substituents at nitrogen undergo cyclisation induced by an electrophile, giving spirocyclic compounds or doubly spirocyclic compounds in which both the nucleophilic and electrophilic heterocycles are dearomatised. © 2009 The Royal Society of Chemistry.
    Original languageEnglish
    Pages (from-to)1964-1966
    Number of pages2
    JournalChemical Communications
    Issue number15
    DOIs
    Publication statusPublished - 2009

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