Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles

Dimitrios Missirlis; Ryuzo Kawamura; Nicola Tirelli; Jeffrey A. Hubbell

doi:10.1016/j.ejps.2006.06.003

Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles

Dimitrios Missirlis, Ryuzo Kawamura, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journal › Article › peer-review

Abstract

We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic® F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 °C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics. © 2006.

Original language	English
Pages (from-to)	120-129
Number of pages	9
Journal	European Journal of Pharmaceutical Sciences
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.ejps.2006.06.003
Publication status	Published - 1 Oct 2006

Keywords

Delivery system
Hydrophobic interactions
Inverse emulsion
Photopolymerization
Poloxamer

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10.1016/j.ejps.2006.06.003

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title = "Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles",

abstract = "We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic{\textregistered} F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 °C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics. {\textcopyright} 2006.",

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author = "Dimitrios Missirlis and Ryuzo Kawamura and Nicola Tirelli and Hubbell, {Jeffrey A.}",

year = "2006",

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doi = "10.1016/j.ejps.2006.06.003",

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T1 - Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles

AU - Missirlis, Dimitrios

AU - Kawamura, Ryuzo

AU - Tirelli, Nicola

AU - Hubbell, Jeffrey A.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic® F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 °C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics. © 2006.

AB - We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic® F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 °C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics. © 2006.

KW - Delivery system

KW - Hydrophobic interactions

KW - Inverse emulsion

KW - Photopolymerization

KW - Poloxamer

U2 - 10.1016/j.ejps.2006.06.003

DO - 10.1016/j.ejps.2006.06.003

M3 - Article

SN - 0928-0987

VL - 29

SP - 120

EP - 129

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 2

ER -

Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles

Abstract

Keywords

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