Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release

Raul Augustin Mitran; Silviu Năstase; Cristina Stan; Andreea Iulia Iorgu; Cristian Matei; Daniela Berger

Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release

Raul Augustin Mitran, Silviu Năstase, Cristina Stan, Andreea Iulia Iorgu, Cristian Matei, Daniela Berger

Department of Chemistry

Research output: Contribution to journal › Conference article › peer-review

Abstract

The doxycycline encapsulation procedure on mesoporous SBA-15 silica has been studied and optimized. The supports (SBA-15 and aminopropyl-modified SBA-15) and hybrid materials containing doxycycline were synthesized and characterized by small and wide angle powder X-ray diffraction, N₂ adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy and thermal analysis. Doxycycline uptake and its release profiles in phosphate buffer solution at pH 5.5 and 37 oC were determined by UV-VIS spectroscopy. The doxycycline encapsulation protocol onto the mesoporous supports was established.

Original language	English
Pages (from-to)	53-60
Number of pages	8
Journal	International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM
Volume	1
Issue number	6
Publication status	Published - 2014
Event	14th International Multidisciplinary Scientific Geoconference and EXPO, SGEM 2014 - Albena, Bulgaria Duration: 17 Jun 2014 → 26 Jun 2014

Keywords

Doxycycline
Drug delivery systems
Mesoporous silica
SBA-15

Cite this

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title = "Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release",

abstract = "The doxycycline encapsulation procedure on mesoporous SBA-15 silica has been studied and optimized. The supports (SBA-15 and aminopropyl-modified SBA-15) and hybrid materials containing doxycycline were synthesized and characterized by small and wide angle powder X-ray diffraction, N2 adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy and thermal analysis. Doxycycline uptake and its release profiles in phosphate buffer solution at pH 5.5 and 37 oC were determined by UV-VIS spectroscopy. The doxycycline encapsulation protocol onto the mesoporous supports was established.",

keywords = "Doxycycline, Drug delivery systems, Mesoporous silica, SBA-15",

author = "Mitran, {Raul Augustin} and Silviu N{\u a}stase and Cristina Stan and Iorgu, {Andreea Iulia} and Cristian Matei and Daniela Berger",

note = "Publisher Copyright: {\textcopyright} SGEM2014. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.; 14th International Multidisciplinary Scientific Geoconference and EXPO, SGEM 2014 ; Conference date: 17-06-2014 Through 26-06-2014",

year = "2014",

language = "English",

volume = "1",

pages = "53--60",

journal = "International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM",

issn = "1314-2704",

publisher = "International Multidisciplinary Scientific Geoconference",

number = "6",

}

Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release. / Mitran, Raul Augustin; Năstase, Silviu; Stan, Cristina et al.
In: International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM, Vol. 1, No. 6, 2014, p. 53-60.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release

AU - Mitran, Raul Augustin

AU - Năstase, Silviu

AU - Stan, Cristina

AU - Iorgu, Andreea Iulia

AU - Matei, Cristian

AU - Berger, Daniela

PY - 2014

Y1 - 2014

N2 - The doxycycline encapsulation procedure on mesoporous SBA-15 silica has been studied and optimized. The supports (SBA-15 and aminopropyl-modified SBA-15) and hybrid materials containing doxycycline were synthesized and characterized by small and wide angle powder X-ray diffraction, N2 adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy and thermal analysis. Doxycycline uptake and its release profiles in phosphate buffer solution at pH 5.5 and 37 oC were determined by UV-VIS spectroscopy. The doxycycline encapsulation protocol onto the mesoporous supports was established.

AB - The doxycycline encapsulation procedure on mesoporous SBA-15 silica has been studied and optimized. The supports (SBA-15 and aminopropyl-modified SBA-15) and hybrid materials containing doxycycline were synthesized and characterized by small and wide angle powder X-ray diffraction, N2 adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy and thermal analysis. Doxycycline uptake and its release profiles in phosphate buffer solution at pH 5.5 and 37 oC were determined by UV-VIS spectroscopy. The doxycycline encapsulation protocol onto the mesoporous supports was established.

KW - Doxycycline

KW - Drug delivery systems

KW - Mesoporous silica

KW - SBA-15

UR - http://www.scopus.com/inward/record.url?scp=84944730335&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:84944730335

SN - 1314-2704

VL - 1

SP - 53

EP - 60

JO - International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM

JF - International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM

IS - 6

T2 - 14th International Multidisciplinary Scientific Geoconference and EXPO, SGEM 2014

Y2 - 17 June 2014 through 26 June 2014

ER -

Doxycycline encapsulation studies into mesoporous SBA-15 silica type carriers and in vitro release

Abstract

Keywords

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