Drosophila melanogaster: A case study of a model genomic sequence and its consequences

Michael Ashburner, Casey M. Bergman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The sequencing and annotation of the Drosophila melanogaster genome, first published in 2000 through collaboration between Celera Genomics and the Drosophila Genome Projects, has provided a number of important contributions to genome research. By demonstrating the utility of methods such as whole-genome shotgun sequencing and genome annotation by a community "jamboree," the Drosophila genome established the precedents for the current paradigm used by most genome projects. Subsequent releases of the initial genome sequence have been improved by the Berkeley Drosophila Genome Project and annotated by FlyBase, the Drosophila community database, providing one of the highest-quality genome sequences and annotations for any organism. We discuss the impact of the growing number of genome sequences now available in the genus on current Drosophila research, and some of the biological questions that these resources will enable to be solved in the future. ©2005 by Cold Spring Harbor Laboratory Press.
    Original languageEnglish
    Pages (from-to)1661-1667
    Number of pages6
    JournalGenome research
    Volume15
    Issue number12
    DOIs
    Publication statusPublished - Dec 2005

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