Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom, Francesco Iorio, Patrick A. Eyers, K. Jane Escott, Shirley Hopper, Andrew Wells, Andrew Doig, Tim Guilliams, Joanna Latimer, Christine Mcnamee, Alan Norris, Philippe Sanseau, David Cavalla, Munir Pirmohamed

Research output: Contribution to journalArticlepeer-review


Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing.
Original languageEnglish
Pages (from-to)41-58
JournalNature Reviews Drug Discovery
Early online date12 Oct 2018
Publication statusPublished - 2018


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