@article{ef82b8196c394240b1e8633bb1142d89,
title = "Dual-binding conjugates of diaromatic guanidines and porphyrins for recognition of G-quadruplexes",
abstract = "The first conceptualised class of dual-binding guanine quadruplex binders has been designed, synthesised and biophysically studied. These compounds combine diaromatic guanidinium systems and neutral tetra-phenylporphyrins (classical binding moiety for guanine quadruplexes) by means of a semi-rigid linker. An extensive screening of a variety of guanine quadruplex structures and double stranded DNA via UV-vis, FRET and CD experiments revealed the preference of the conjugates towards guanine quadruplexes. Additionally, docking studies indicate the potential dual mode of binding.",
author = "Jagdeep Grover and Cristina Trujillo and Mona Saad and Ganapathi Emandi and Nikolina Stipani{\v c}ev and Bernhard, {Stefan S.R.} and Aurore Gu{\'e}din and Mergny, {Jean Louis} and Senge, {Mathias O.} and Isabel Rozas",
note = "Funding Information: We acknowledge the Irish Research Council for a postdoctoral fellowship (GOIPD/2016/380, J. G.) and a postgraduate award (GOIPG/2018/2336, N. S.), the Science Foundation Ireland (IvP-13/IA/1894) for support, and the ICHEC for providing computational facilities. We thank Prof. D. Grayson for the generous gift of TPP, P. Chenne for her help in preparing the starting materials, and Dr. J. O{\textquoteright}Brien and G. Hessman for performing the NMR and HRMS experiments. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = aug,
day = "7",
doi = "10.1039/d0ob01264e",
language = "English",
volume = "18",
pages = "5617--5624",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "29",
}