Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Jonathan M. Bernstein; Jarrod J. Homer; Catharine M. West

doi:10.1016/j.oraloncology.2014.07.011

Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Jonathan M. Bernstein, Jarrod J. Homer, Catharine M. West

Research output: Contribution to journal › Article › peer-review

Abstract

© 2014 Elsevier Ltd. All rights reserved.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (Ktrans), higher overall Ktrans or lower skewness of Ktrans were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies.

Original language	English
Pages (from-to)	963-970
Number of pages	7
Journal	Oral Oncology
Volume	50
Issue number	10
DOIs	https://doi.org/10.1016/j.oraloncology.2014.07.011
Publication status	Published - 1 Oct 2014

Keywords

Biomarker
Dynamic contrast-enhanced magnetic
Head and neck cancer
Hypoxia
Perfusion imaging
resonance imaging (DCE-MRI)

UN SDGs

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10.1016/j.oraloncology.2014.07.011

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title = "Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review",

abstract = "{\textcopyright} 2014 Elsevier Ltd. All rights reserved.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (Ktrans), higher overall Ktrans or lower skewness of Ktrans were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies.",

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AU - Bernstein, Jonathan M.

AU - Homer, Jarrod J.

AU - West, Catharine M.

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Y1 - 2014/10/1

N2 - © 2014 Elsevier Ltd. All rights reserved.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (Ktrans), higher overall Ktrans or lower skewness of Ktrans were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies.

AB - © 2014 Elsevier Ltd. All rights reserved.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (Ktrans), higher overall Ktrans or lower skewness of Ktrans were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies.

KW - Biomarker

KW - Dynamic contrast-enhanced magnetic

KW - Head and neck cancer

KW - Hypoxia

KW - Perfusion imaging

KW - resonance imaging (DCE-MRI)

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DO - 10.1016/j.oraloncology.2014.07.011

M3 - Article

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SN - 1368-8375

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SP - 963

EP - 970

JO - Oral Oncology

JF - Oral Oncology

IS - 10

ER -

Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Abstract

Keywords

UN SDGs

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