Dynamic control of head mesoderm patterning

I. Bothe, G. Tenin, A. Oseni, Susanne Dietrich

    Research output: Contribution to journalArticlepeer-review


    The embryonic head mesoderm gives rise to cranial muscle and contributes to the skull and heart. Prior to differentiation, the tissue is regionalised by the means of molecular markers. We show that this pattern is established in three discrete phases, all depending on extrinsic cues. Assaying for direct and first-wave indirect responses, we found that the process is controlled by dynamic combinatorial as well as antagonistic action of retinoic acid (RA), Bmp and Fgf signalling. In phase 1, the initial anteroposterior (a-p) subdivision of the head mesoderm is laid down in response to falling RA levels and activation of Fgf signalling. In phase 2, Bmp and Fgf signalling reinforce the a-p boundary and refine anterior marker gene expression. In phase 3, spreading Fgf signalling drives the a-p expansion of MyoR and Tbx1 expression along the pharynx, with RA limiting the expansion of MyoR. This establishes the mature head mesoderm pattern with markers distinguishing between the prospective extra-ocular and jaw skeletal muscles, the branchiomeric muscles and the cells for the outflow tract of the heart.
    Original languageEnglish
    Pages (from-to)2807-2821
    Number of pages15
    Issue number13
    Publication statusPublished - 2011


    Dive into the research topics of 'Dynamic control of head mesoderm patterning'. Together they form a unique fingerprint.

    Cite this