Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme

Zhi Gang Chen; Monika A. Zietek; Henry J. Russell; Shirley Tait; Sam Hay; Alex R. Jones; Nigel S. Scrutton

doi:10.1002/cbic.201300420

Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme

Zhi Gang Chen, Monika A. Zietek, Henry J. Russell, Shirley Tait, Sam Hay, Alex R. Jones, Nigel S. Scrutton

Research output: Contribution to journal › Article › peer-review

Abstract

Radical control: A single glutamate residue (E287) in the coenzyme B12-dependent ethanolamine ammonia lyase is pivotal to generating high-energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1529-1533
Number of pages	4
Journal	ChemBioChem: a European journal of chemical biology
Volume	14
Issue number	13
DOIs	https://doi.org/10.1002/cbic.201300420
Publication status	Published - Sept 2013

Keywords

Coenzyme B12
Electrostatics
Enzymes
Protein dynamics
Radicals

Research Beacons, Institutes and Platforms

Photon Science Institute

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10.1002/cbic.201300420

Linking experiment to theory: Quantum entanglement during enzyme catalysis - Dr S Hay fellowship
Hay, S. (PI)
1/09/10 → 31/08/15
Project: Research

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title = "Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme",

abstract = "Radical control: A single glutamate residue (E287) in the coenzyme B12-dependent ethanolamine ammonia lyase is pivotal to generating high-energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions. {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "Coenzyme B12, Electrostatics, Enzymes, Protein dynamics, Radicals",

author = "Chen, {Zhi Gang} and Zietek, {Monika A.} and Russell, {Henry J.} and Shirley Tait and Sam Hay and Jones, {Alex R.} and Scrutton, {Nigel S.}",

note = ", Biotechnology and Biological Sciences Research Council, United Kingdom",

year = "2013",

month = sep,

doi = "10.1002/cbic.201300420",

language = "English",

volume = "14",

pages = "1529--1533",

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T1 - Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme

AU - Chen, Zhi Gang

AU - Zietek, Monika A.

AU - Russell, Henry J.

AU - Tait, Shirley

AU - Hay, Sam

AU - Jones, Alex R.

AU - Scrutton, Nigel S.

N1 - , Biotechnology and Biological Sciences Research Council, United Kingdom

PY - 2013/9

Y1 - 2013/9

N2 - Radical control: A single glutamate residue (E287) in the coenzyme B12-dependent ethanolamine ammonia lyase is pivotal to generating high-energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Radical control: A single glutamate residue (E287) in the coenzyme B12-dependent ethanolamine ammonia lyase is pivotal to generating high-energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - Coenzyme B12

KW - Electrostatics

KW - Enzymes

KW - Protein dynamics

KW - Radicals

U2 - 10.1002/cbic.201300420

DO - 10.1002/cbic.201300420

M3 - Article

C2 - 23959797

SN - 1439-7633

VL - 14

SP - 1529

EP - 1533

JO - ChemBioChem: a European journal of chemical biology

JF - ChemBioChem: a European journal of chemical biology

IS - 13

ER -

Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme

Abstract

Keywords

Research Beacons, Institutes and Platforms

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Projects

Linking experiment to theory: Quantum entanglement during enzyme catalysis - Dr S Hay fellowship

Cite this