Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Mark S. Williams; Tim C. P. Somervaille

doi:10.1080/23723556.2019.1705730

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Mark S. Williams, Tim C. P. Somervaille

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increased ABCB1 expression and allows leukemia cells to escape from targeted third-generation ABCB1 inhibition.

Original language	English
Pages (from-to)	1705730
Journal	Molecular & cellular oncology
Volume	7
Issue number	2
Early online date	8 Jan 2020
DOIs	https://doi.org/10.1080/23723556.2019.1705730
Publication status	Published - 3 Mar 2020

Research Beacons, Institutes and Platforms

Lydia Becker Institute
Manchester Cancer Research Centre

UN SDGs

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10.1080/23723556.2019.1705730

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title = "Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia",

abstract = "The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increased ABCB1 expression and allows leukemia cells to escape from targeted third-generation ABCB1 inhibition.",

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Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Abstract

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UN SDGs

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