Dynamics of Endosomal Sorting

Naomi E. Bishop

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The endocytic pathway receives cargo from the cell surface via endocytosis, biosynthetic cargo from the late Golgi complex, and various molecules from the cytoplasm via autophagy. This review focuses on the dynamics of the endocytic pathway in relationship to these processes and covers new information about the sorting events and molecular complexes involved. The following areas are discussed: dynamics at the plasma membrane, sorting within early endosomes and recycling to the cell surface, the role of the cytoskeleton, transport to late endosomes and sorting into multivesicular bodies, anterograde and retrograde Golgi transport, as well as the autophagic pathway.
    Original languageEnglish
    Pages (from-to)1-57
    Number of pages56
    JournalInternational Review of Cytology
    Volume232
    DOIs
    Publication statusPublished - 2003

    Keywords

    • Autophagy
    • Cytoskeleton
    • Endocytosis
    • Endosome
    • Golgi complex
    • Lysosome
    • Protein sorting
    • Vesicular transport

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