Early breaking strength of repaired flexor tendon treated with 5-fluorouracil

S. Cerovac; A. Afoke; A. Akali; D. A. McGrouther

doi:10.1054/jhsb.2000.0537

Early breaking strength of repaired flexor tendon treated with 5-fluorouracil

S. Cerovac, A. Afoke, A. Akali, D. A. McGrouther

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.

Original language	English
Pages (from-to)	220-223
Number of pages	3
Journal	Journal of Hand Surgery (European Volume)
Volume	26
Issue number	3
DOIs	https://doi.org/10.1054/jhsb.2000.0537
Publication status	Published - 2001

Keywords

Adhesions/physiopathology
Animal
Fluorouracil/*pharmacology
Male
Rabbits
Sutures
Tendon Injuries/physiopathology/*surgery
Tensile Strength
Wound Healing/*drug effects

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10.1054/jhsb.2000.0537

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title = "Early breaking strength of repaired flexor tendon treated with 5-fluorouracil",

abstract = "This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.",

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T1 - Early breaking strength of repaired flexor tendon treated with 5-fluorouracil

AU - Cerovac, S.

AU - Afoke, A.

AU - Akali, A.

AU - McGrouther, D. A.

N1 - 212810870266-7681Journal Article

PY - 2001

Y1 - 2001

N2 - This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.

AB - This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.

KW - Adhesions/physiopathology

KW - Animal

KW - Fluorouracil/pharmacology

KW - Male

KW - Rabbits

KW - Sutures

KW - Tendon Injuries/physiopathology/surgery

KW - Tensile Strength

KW - Wound Healing/drug effects

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DO - 10.1054/jhsb.2000.0537

M3 - Article

SN - 1753-1934

VL - 26

SP - 220

EP - 223

JO - Journal of Hand Surgery (European Volume)

JF - Journal of Hand Surgery (European Volume)

IS - 3

ER -

Early breaking strength of repaired flexor tendon treated with 5-fluorouracil

Abstract

Keywords

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