Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

Jeremy R. Parr; Ann Le Couteur; Gillian Baird; Michael Rutter; Andrew Pickles; Eric Fombonne; Anthony J. Bailey; Simon Wallace; Kerstin Wittemeyer; Anthony Monaco; Gabrielle Barnby; Patrick Bolton; Janette Moore; Marianna Murin; Helen McConachie; Tom Berney; Zoe Docherty; Stephen Abbs; Caroline Ogilvie; Pamela Warburton; Janine Lamb; Jonathan Green; Bryan Bolton; Ros Packer; Demetrious Haracopos; Lennart Pedersen; Torben Isager; Karen Brondum-Nielsen; Bernadette Roge; Maïté Tauber; Carine Mantoulan; Fritz Poustka; Sven Bölte; Sabine Feineis-Matthews; Dorothea Rühl; Gabriele Schmötzer; Annemarie Poustka; Sabine M. Klauck; John Tsiantis; Katerina Papanikolaou; Elena Maestrini; Herman Van Engeland; Maretha De Jonge; Catherine Lord; Christina Corsello; Edwin Cook; Jeff Salt; Stephen Guter; Bennett Leventhal; Fred Volkmar; Kathleen Koenig

doi:10.1007/s10803-010-1055-2

Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

Jeremy R. Parr, Ann Le Couteur, Gillian Baird, Michael Rutter, Andrew Pickles, Eric Fombonne, Anthony J. Bailey, Simon Wallace, Kerstin Wittemeyer, Anthony Monaco, Gabrielle Barnby, Patrick Bolton, Janette Moore, Marianna Murin, Helen McConachie, Tom Berney, Zoe Docherty, Stephen Abbs, Caroline Ogilvie, Pamela WarburtonJanine Lamb, Jonathan Green, Bryan Bolton, Ros Packer, Demetrious Haracopos, Lennart Pedersen, Torben Isager, Karen Brondum-Nielsen, Bernadette Roge, Maïté Tauber, Carine Mantoulan, Fritz Poustka, Sven Bölte, Sabine Feineis-Matthews, Dorothea Rühl, Gabriele Schmötzer, Annemarie Poustka, Sabine M. Klauck, John Tsiantis, Katerina Papanikolaou, Elena Maestrini, Herman Van Engeland, Maretha De Jonge, Catherine Lord, Christina Corsello, Edwin Cook, Jeff Salt, Stephen Guter, Bennett Leventhal, Fred Volkmar, Kathleen Koenig

Research output: Contribution to journal › Article › peer-review

Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.

Original language	English
Pages (from-to)	332-340
Number of pages	8
Journal	Journal of Autism and Developmental Disorders
Volume	41
Issue number	3
DOIs	https://doi.org/10.1007/s10803-010-1055-2
Publication status	Published - Mar 2011

Keywords

ASD
Concordance
Development
Genetics
Language
Regression

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10.1007/s10803-010-1055-2

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Parr, J. R., Le Couteur, A., Baird, G., Rutter, M., Pickles, A., Fombonne, E., Bailey, A. J., Wallace, S., Wittemeyer, K., Monaco, A., Barnby, G., Bolton, P., Moore, J., Murin, M., McConachie, H., Berney, T., Docherty, Z., Abbs, S., Ogilvie, C., ... Koenig, K. (2011). Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders, 41(3), 332-340. https://doi.org/10.1007/s10803-010-1055-2

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title = "Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample",

abstract = "The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. {\textcopyright} Springer Science+Business Media, LLC 2010.",

keywords = "ASD, Concordance, Development, Genetics, Language, Regression",

author = "Parr, {Jeremy R.} and {Le Couteur}, Ann and Gillian Baird and Michael Rutter and Andrew Pickles and Eric Fombonne and Bailey, {Anthony J.} and Simon Wallace and Kerstin Wittemeyer and Anthony Monaco and Gabrielle Barnby and Patrick Bolton and Janette Moore and Marianna Murin and Helen McConachie and Tom Berney and Zoe Docherty and Stephen Abbs and Caroline Ogilvie and Pamela Warburton and Janine Lamb and Jonathan Green and Bryan Bolton and Ros Packer and Demetrious Haracopos and Lennart Pedersen and Torben Isager and Karen Brondum-Nielsen and Bernadette Roge and Ma{\"i}t{\'e} Tauber and Carine Mantoulan and Fritz Poustka and Sven B{\"o}lte and Sabine Feineis-Matthews and Dorothea R{\"u}hl and Gabriele Schm{\"o}tzer and Annemarie Poustka and Klauck, {Sabine M.} and John Tsiantis and Katerina Papanikolaou and Elena Maestrini and {Van Engeland}, Herman and {De Jonge}, Maretha and Catherine Lord and Christina Corsello and Edwin Cook and Jeff Salt and Stephen Guter and Bennett Leventhal and Fred Volkmar and Kathleen Koenig",

year = "2011",

month = mar,

doi = "10.1007/s10803-010-1055-2",

language = "English",

volume = "41",

pages = "332--340",

journal = "Journal of Autism and Developmental Disorders",

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Parr, JR, Le Couteur, A, Baird, G, Rutter, M, Pickles, A, Fombonne, E, Bailey, AJ, Wallace, S, Wittemeyer, K, Monaco, A, Barnby, G, Bolton, P, Moore, J, Murin, M, McConachie, H, Berney, T, Docherty, Z, Abbs, S, Ogilvie, C, Warburton, P, Lamb, J , Green, J, Bolton, B, Packer, R, Haracopos, D, Pedersen, L, Isager, T, Brondum-Nielsen, K, Roge, B, Tauber, M, Mantoulan, C, Poustka, F, Bölte, S, Feineis-Matthews, S, Rühl, D, Schmötzer, G, Poustka, A, Klauck, SM, Tsiantis, J, Papanikolaou, K, Maestrini, E, Van Engeland, H, De Jonge, M, Lord, C, Corsello, C, Cook, E, Salt, J, Guter, S, Leventhal, B, Volkmar, F & Koenig, K 2011, 'Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample', Journal of Autism and Developmental Disorders, vol. 41, no. 3, pp. 332-340. https://doi.org/10.1007/s10803-010-1055-2

TY - JOUR

T1 - Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

AU - Parr, Jeremy R.

AU - Le Couteur, Ann

AU - Baird, Gillian

AU - Rutter, Michael

AU - Pickles, Andrew

AU - Fombonne, Eric

AU - Bailey, Anthony J.

AU - Wallace, Simon

AU - Wittemeyer, Kerstin

AU - Monaco, Anthony

AU - Barnby, Gabrielle

AU - Bolton, Patrick

AU - Moore, Janette

AU - Murin, Marianna

AU - McConachie, Helen

AU - Berney, Tom

AU - Docherty, Zoe

AU - Abbs, Stephen

AU - Ogilvie, Caroline

AU - Warburton, Pamela

AU - Lamb, Janine

AU - Green, Jonathan

AU - Bolton, Bryan

AU - Packer, Ros

AU - Haracopos, Demetrious

AU - Pedersen, Lennart

AU - Isager, Torben

AU - Brondum-Nielsen, Karen

AU - Roge, Bernadette

AU - Tauber, Maïté

AU - Mantoulan, Carine

AU - Poustka, Fritz

AU - Bölte, Sven

AU - Feineis-Matthews, Sabine

AU - Rühl, Dorothea

AU - Schmötzer, Gabriele

AU - Poustka, Annemarie

AU - Klauck, Sabine M.

AU - Tsiantis, John

AU - Papanikolaou, Katerina

AU - Maestrini, Elena

AU - Van Engeland, Herman

AU - De Jonge, Maretha

AU - Lord, Catherine

AU - Corsello, Christina

AU - Cook, Edwin

AU - Salt, Jeff

AU - Guter, Stephen

AU - Leventhal, Bennett

AU - Volkmar, Fred

AU - Koenig, Kathleen

PY - 2011/3

Y1 - 2011/3

N2 - The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.

AB - The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.

KW - ASD

KW - Concordance

KW - Development

KW - Genetics

KW - Language

KW - Regression

U2 - 10.1007/s10803-010-1055-2

DO - 10.1007/s10803-010-1055-2

M3 - Article

C2 - 20711649

SN - 0162-3257

VL - 41

SP - 332

EP - 340

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 3

ER -

Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

Abstract

Keywords

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