Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes

Jeroen Walpot; João R Inácio; Samia Massalha; Huda El Mais; Alomgir Hossain; Judy Shiau; Gary R Small; Andrew M Crean; Yeung Yam; Frank Rybicki; Benjamin J W Chow

doi:10.1016/j.orcp.2019.07.002

Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes

Jeroen Walpot, João R Inácio, Samia Massalha, Huda El Mais, Alomgir Hossain, Judy Shiau, Gary R Small, Andrew M Crean, Yeung Yam, Frank Rybicki, Benjamin J W Chow

Division of Cardiovascular Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Obesity is an in independent risk factor for cardiovascular disease.

GOAL: To describe the early LV remodelling pattern in patients with overweight and obesity and structurally normal hearts.

METHODS: Consecutive patients (n = 2374), with structurally normal hearts and BMI ≥ 18.5 kg/m2, undergoing prospective mid-diastolic ECG gated CTCA were selected. Left ventricular mass (LVM) and Left ventricular mid-diastolic volume (LVMDV) were measured. The concentricity index (LVM/LVMDV) were calculated. According to the definitions of the World Health Organization (WHO), the patients were divided into weight categories.

RESULTS: The mean LVM ± Std. deviation in the subgroups according to WHO classification was 101.68 ± 28.99 g (normal weight), 115.79 ± 29.14 g (overweight), 123.8 ± 33.44 g (class I obesity), 125.85 ± 32.89 g (class II obesity) and 132.45 ± 37.85 g (class III obesity). (p < 0.001) The mean LVMDV progressed with increasing WHO weight category from 112.37 ± 36.46 in patients with normal BMI to 140.26 ± 43.78 in patients with class III obesity. (p < 0.001) The concentricity index was 0.935 ± 0.216 g/ml in patients with normal BMI, 0.979 ± 0.253 g/ml, 1.058 ± 0.635 g/ml, 0.996 ± 0.284 g/ml and 0.9768 ± 0.244 g/ml in patients with BMI categories 25-29.99, 30-34.99, 35-39.99 and ≥40 kg/m2, respectively.

CONCLUSIONS: Our study demonstrates a non-linear (inverse U-shape) relationship between increasing BMI class and concentricity index, reaching its maximum at a BMI of 30-34.99 kg/m2. Further increase in BMI results in LV dilation.

Original language	English
Pages (from-to)	478-485
Number of pages	8
Journal	Obesity Research and Clinical Practice
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/j.orcp.2019.07.002
Publication status	Published - 2019

Keywords

Adult
Aged
Body Mass Index
Feasibility Studies
Female
Heart Ventricles/diagnostic imaging
Humans
Male
Middle Aged
Obesity/physiopathology
Overweight/physiopathology
Prospective Studies
Tomography, X-Ray Computed/methods
Ventricular Remodeling/physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.orcp.2019.07.002

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Walpot, J., Inácio, J. R., Massalha, S., El Mais, H., Hossain, A., Shiau, J., Small, G. R., Crean, A. M., Yam, Y., Rybicki, F., & Chow, B. J. W. (2019). Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes. Obesity Research and Clinical Practice, 13(5), 478-485. https://doi.org/10.1016/j.orcp.2019.07.002

@article{fa6691f0a0ee4446a9127772ea5bc093,

title = "Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes",

abstract = "BACKGROUND: Obesity is an in independent risk factor for cardiovascular disease.GOAL: To describe the early LV remodelling pattern in patients with overweight and obesity and structurally normal hearts.METHODS: Consecutive patients (n = 2374), with structurally normal hearts and BMI ≥ 18.5 kg/m2, undergoing prospective mid-diastolic ECG gated CTCA were selected. Left ventricular mass (LVM) and Left ventricular mid-diastolic volume (LVMDV) were measured. The concentricity index (LVM/LVMDV) were calculated. According to the definitions of the World Health Organization (WHO), the patients were divided into weight categories.RESULTS: The mean LVM ± Std. deviation in the subgroups according to WHO classification was 101.68 ± 28.99 g (normal weight), 115.79 ± 29.14 g (overweight), 123.8 ± 33.44 g (class I obesity), 125.85 ± 32.89 g (class II obesity) and 132.45 ± 37.85 g (class III obesity). (p < 0.001) The mean LVMDV progressed with increasing WHO weight category from 112.37 ± 36.46 in patients with normal BMI to 140.26 ± 43.78 in patients with class III obesity. (p < 0.001) The concentricity index was 0.935 ± 0.216 g/ml in patients with normal BMI, 0.979 ± 0.253 g/ml, 1.058 ± 0.635 g/ml, 0.996 ± 0.284 g/ml and 0.9768 ± 0.244 g/ml in patients with BMI categories 25-29.99, 30-34.99, 35-39.99 and ≥40 kg/m2, respectively.CONCLUSIONS: Our study demonstrates a non-linear (inverse U-shape) relationship between increasing BMI class and concentricity index, reaching its maximum at a BMI of 30-34.99 kg/m2. Further increase in BMI results in LV dilation.",

keywords = "Adult, Aged, Body Mass Index, Feasibility Studies, Female, Heart Ventricles/diagnostic imaging, Humans, Male, Middle Aged, Obesity/physiopathology, Overweight/physiopathology, Prospective Studies, Tomography, X-Ray Computed/methods, Ventricular Remodeling/physiology",

author = "Jeroen Walpot and In{\'a}cio, \{Jo{\~a}o R\} and Samia Massalha and \{El Mais\}, Huda and Alomgir Hossain and Judy Shiau and Small, \{Gary R\} and Crean, \{Andrew M\} and Yeung Yam and Frank Rybicki and Chow, \{Benjamin J W\}",

year = "2019",

doi = "10.1016/j.orcp.2019.07.002",

language = "English",

volume = "13",

pages = "478--485",

journal = "Obesity Research and Clinical Practice",

issn = "1871-403X",

publisher = "Elsevier BV",

number = "5",

}

Walpot, J, Inácio, JR, Massalha, S, El Mais, H, Hossain, A, Shiau, J, Small, GR, Crean, AM, Yam, Y, Rybicki, F & Chow, BJW 2019, 'Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes', Obesity Research and Clinical Practice, vol. 13, no. 5, pp. 478-485. https://doi.org/10.1016/j.orcp.2019.07.002

TY - JOUR

T1 - Early LV remodelling patterns in overweight and obesity

T2 - Feasibility of cardiac CT to detect early geometric left ventricular changes

AU - Walpot, Jeroen

AU - Inácio, João R

AU - Massalha, Samia

AU - El Mais, Huda

AU - Hossain, Alomgir

AU - Shiau, Judy

AU - Small, Gary R

AU - Crean, Andrew M

AU - Yam, Yeung

AU - Rybicki, Frank

AU - Chow, Benjamin J W

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Obesity is an in independent risk factor for cardiovascular disease.GOAL: To describe the early LV remodelling pattern in patients with overweight and obesity and structurally normal hearts.METHODS: Consecutive patients (n = 2374), with structurally normal hearts and BMI ≥ 18.5 kg/m2, undergoing prospective mid-diastolic ECG gated CTCA were selected. Left ventricular mass (LVM) and Left ventricular mid-diastolic volume (LVMDV) were measured. The concentricity index (LVM/LVMDV) were calculated. According to the definitions of the World Health Organization (WHO), the patients were divided into weight categories.RESULTS: The mean LVM ± Std. deviation in the subgroups according to WHO classification was 101.68 ± 28.99 g (normal weight), 115.79 ± 29.14 g (overweight), 123.8 ± 33.44 g (class I obesity), 125.85 ± 32.89 g (class II obesity) and 132.45 ± 37.85 g (class III obesity). (p < 0.001) The mean LVMDV progressed with increasing WHO weight category from 112.37 ± 36.46 in patients with normal BMI to 140.26 ± 43.78 in patients with class III obesity. (p < 0.001) The concentricity index was 0.935 ± 0.216 g/ml in patients with normal BMI, 0.979 ± 0.253 g/ml, 1.058 ± 0.635 g/ml, 0.996 ± 0.284 g/ml and 0.9768 ± 0.244 g/ml in patients with BMI categories 25-29.99, 30-34.99, 35-39.99 and ≥40 kg/m2, respectively.CONCLUSIONS: Our study demonstrates a non-linear (inverse U-shape) relationship between increasing BMI class and concentricity index, reaching its maximum at a BMI of 30-34.99 kg/m2. Further increase in BMI results in LV dilation.

AB - BACKGROUND: Obesity is an in independent risk factor for cardiovascular disease.GOAL: To describe the early LV remodelling pattern in patients with overweight and obesity and structurally normal hearts.METHODS: Consecutive patients (n = 2374), with structurally normal hearts and BMI ≥ 18.5 kg/m2, undergoing prospective mid-diastolic ECG gated CTCA were selected. Left ventricular mass (LVM) and Left ventricular mid-diastolic volume (LVMDV) were measured. The concentricity index (LVM/LVMDV) were calculated. According to the definitions of the World Health Organization (WHO), the patients were divided into weight categories.RESULTS: The mean LVM ± Std. deviation in the subgroups according to WHO classification was 101.68 ± 28.99 g (normal weight), 115.79 ± 29.14 g (overweight), 123.8 ± 33.44 g (class I obesity), 125.85 ± 32.89 g (class II obesity) and 132.45 ± 37.85 g (class III obesity). (p < 0.001) The mean LVMDV progressed with increasing WHO weight category from 112.37 ± 36.46 in patients with normal BMI to 140.26 ± 43.78 in patients with class III obesity. (p < 0.001) The concentricity index was 0.935 ± 0.216 g/ml in patients with normal BMI, 0.979 ± 0.253 g/ml, 1.058 ± 0.635 g/ml, 0.996 ± 0.284 g/ml and 0.9768 ± 0.244 g/ml in patients with BMI categories 25-29.99, 30-34.99, 35-39.99 and ≥40 kg/m2, respectively.CONCLUSIONS: Our study demonstrates a non-linear (inverse U-shape) relationship between increasing BMI class and concentricity index, reaching its maximum at a BMI of 30-34.99 kg/m2. Further increase in BMI results in LV dilation.

KW - Adult

KW - Aged

KW - Body Mass Index

KW - Feasibility Studies

KW - Female

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Male

KW - Middle Aged

KW - Obesity/physiopathology

KW - Overweight/physiopathology

KW - Prospective Studies

KW - Tomography, X-Ray Computed/methods

KW - Ventricular Remodeling/physiology

UR - https://www.scopus.com/pages/publications/85070378468

U2 - 10.1016/j.orcp.2019.07.002

DO - 10.1016/j.orcp.2019.07.002

M3 - Article

C2 - 31416719

SN - 1871-403X

VL - 13

SP - 478

EP - 485

JO - Obesity Research and Clinical Practice

JF - Obesity Research and Clinical Practice

IS - 5

ER -

Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes

Abstract

Keywords

UN SDGs

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