Early menstrual characteristics associated with subsequent diagnosis of endometriosis

Susan A. Treloar, Tanya A. Bell, Christina M. Nagle, David M. Purdie, Adèle C. Green

    Research output: Contribution to journalArticlepeer-review


    Objective: The aim of this study was to investigate the association between early menstrual characteristics, before symptom onset, and later diagnosis of endometriosis. Study Design: This was a case-control study of 268 Australian women with surgically confirmed moderate-to-severe endometriosis (cases) and 244 women without endometriosis (controls). Early menstrual cycle characteristics, before age at symptom onset, were analyzed. Results: Menarche after age 14 years was strongly and inversely associated with endometriosis (odds ratio, 0.3; 95% confidence interval, 0.1-0.6). A history of dysmenorrhea was associated with subsequent endometriosis (odds ratio, 2.6; 95% confidence interval, 1.1-6.2). Despite a suggestive trend, shorter menstrual cycle length was not associated with endometriosis. Duration of natural menstruation and heaviness of flow were not associated with subsequent risk of endometriosis; neither was the reported type of sanitary protection used nor history of sexual intercourse during menstruation. Conclusion: There is a decreased risk of endometriosis with late age at menarche and an increased risk in women who report an early history of dysmenorrhea. © 2010 Mosby, Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)534-e6
    JournalAmerican Journal of Obstetrics and Gynecology
    Issue number6
    Publication statusPublished - Jun 2010


    • dysmenorrhea
    • early menstrual characteristics
    • endometriosis
    • etiology
    • menstruation


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