TY - JOUR
T1 - Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity
AU - Bosch-Bayard, Jorge
AU - Razzaq, Fuleah Abdul
AU - Lopez-Naranjo, Carlos
AU - Wang, Ying
AU - Li, Min
AU - Galan-Garcia, Lidice
AU - Calzada-Reyes, Ana
AU - Virues-Alba, Trinidad
AU - Rabinowitz, Arielle G
AU - Suarez-Murias, Carlos
AU - Guo, Yanbo
AU - Sanchez-Castillo, Manuel
AU - Rogers, Kassandra
AU - Gallagher, Anne
AU - Prichep, Leslie
AU - Anderson, Simon G
AU - Michel, Christoph M
AU - Evans, Alan C
AU - Bringas-Vega, Maria L
AU - Galler, Janina R
AU - Valdes-Sosa, Pedro A
N1 - Funding Information:
This study was supported by grants (JRG) from the National Institutes of Health (NIH) (HD060986) and by grants (to PAVS, MLBV, YG, ML, YW, FR) from the National Nature Science Foundation of China NSFC grant No. 61871105 and CNS Program of UESTC (No. Y0301902610100201 ), and (to MLBV and PAVS) from the Nestlé Foundation (Validation of a long-life neural fingerprint of early malnutrition, 2017). JBB was supported by the Fonds de recherche du Québec (FRQ) HBHL FRQ/CCC Axis ( 246117 ), the CFREF/HBHL HIBALL, Helmholtz ( 252428 ), and Brain Canada ( 243030 ).
Funding Information:
This study was supported by grants (JRG) from the National Institutes of Health (NIH) (HD060986) and by grants (to PAVS, MLBV, YG, ML, YW, FR) from the National Nature Science Foundation of China NSFC grant No. 61871105 and CNS Program of UESTC (No. Y0301902610100201), and (to MLBV and PAVS) from the Nestl? Foundation (Validation of a long-life neural fingerprint of early malnutrition, 2017). JBB was supported by the Fonds de recherche du Qu?bec (FRQ) HBHL FRQ/CCC Axis (246117), the CFREF/HBHL HIBALL, Helmholtz (252428), and Brain Canada (243030).
Publisher Copyright:
© 2022
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5-11 years of age and 40 years later at 45-51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.
AB - Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5-11 years of age and 40 years later at 45-51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.
KW - EEG
KW - Longitudinal study
KW - Malnutrition
KW - Source analysis
KW - Tomography
KW - qEEG
U2 - 10.1016/j.neuroimage.2022.119144
DO - 10.1016/j.neuroimage.2022.119144
M3 - Article
C2 - 35342003
SN - 1053-8119
VL - 254
SP - 119144
JO - NeuroImage
JF - NeuroImage
M1 - 119144
ER -
