Ebola Virus Disease in Children, Sierra Leone, 2014-2015

Felicity Fitzgerald; Asad Naveed; Kevin Wing; Musa Gbessay; J C G Ross; Francesco Checchi; Daniel Youkee; Mohammed Boie Jalloh; David Baion; Ayeshatu Mustapha; Hawanatu Jah; Sandra Lako; Shefali Oza; Sabah Boufkhed; Reynold Feury; Julia A Bielicki; Diana M Gibb; Nigel Klein; Foday Sahr; Shunmay Yeung

doi:10.3201/eid2210.160579

Ebola Virus Disease in Children, Sierra Leone, 2014-2015

Felicity Fitzgerald, Asad Naveed, Kevin Wing, Musa Gbessay, J C G Ross, Francesco Checchi, Daniel Youkee, Mohammed Boie Jalloh, David Baion, Ayeshatu Mustapha, Hawanatu Jah, Sandra Lako, Shefali Oza, Sabah Boufkhed, Reynold Feury, Julia A Bielicki, Diana M Gibb, Nigel Klein, Foday Sahr, Shunmay Yeung

Humanitarian Conflict Response Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.

Original language	English
Pages (from-to)	1769-77
Number of pages	9
Journal	Emerging infectious diseases
Volume	22
Issue number	10
DOIs	https://doi.org/10.3201/eid2210.160579
Publication status	Published - 1 Oct 2016

Keywords

Child
Child, Preschool
Cohort Studies
Delivery of Health Care
Disease Outbreaks
Female
Health Status
Hemorrhagic Fever, Ebola/blood
Humans
Male
Retrospective Studies
Risk Factors
Sierra Leone/epidemiology
Treatment Outcome

Research Beacons, Institutes and Platforms

Humanitarian and Conflict Response Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid2210.160579

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Fitzgerald, F., Naveed, A., Wing, K., Gbessay, M., Ross, J. C. G., Checchi, F., Youkee, D., Jalloh, M. B., Baion, D., Mustapha, A., Jah, H., Lako, S., Oza, S., Boufkhed, S., Feury, R., Bielicki, J. A., Gibb, D. M., Klein, N., Sahr, F., & Yeung, S. (2016). Ebola Virus Disease in Children, Sierra Leone, 2014-2015. Emerging infectious diseases, 22(10), 1769-77. https://doi.org/10.3201/eid2210.160579

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title = "Ebola Virus Disease in Children, Sierra Leone, 2014-2015",

abstract = "Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.",

keywords = "Child, Child, Preschool, Cohort Studies, Delivery of Health Care, Disease Outbreaks, Female, Health Status, Hemorrhagic Fever, Ebola/blood, Humans, Male, Retrospective Studies, Risk Factors, Sierra Leone/epidemiology, Treatment Outcome",

author = "Felicity Fitzgerald and Asad Naveed and Kevin Wing and Musa Gbessay and Ross, {J C G} and Francesco Checchi and Daniel Youkee and Jalloh, {Mohammed Boie} and David Baion and Ayeshatu Mustapha and Hawanatu Jah and Sandra Lako and Shefali Oza and Sabah Boufkhed and Reynold Feury and Bielicki, {Julia A} and Gibb, {Diana M} and Nigel Klein and Foday Sahr and Shunmay Yeung",

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doi = "10.3201/eid2210.160579",

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Fitzgerald, F, Naveed, A, Wing, K, Gbessay, M, Ross, JCG, Checchi, F, Youkee, D, Jalloh, MB, Baion, D, Mustapha, A, Jah, H, Lako, S, Oza, S, Boufkhed, S, Feury, R, Bielicki, JA, Gibb, DM, Klein, N, Sahr, F & Yeung, S 2016, 'Ebola Virus Disease in Children, Sierra Leone, 2014-2015', Emerging infectious diseases, vol. 22, no. 10, pp. 1769-77. https://doi.org/10.3201/eid2210.160579

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T1 - Ebola Virus Disease in Children, Sierra Leone, 2014-2015

AU - Fitzgerald, Felicity

AU - Naveed, Asad

AU - Wing, Kevin

AU - Gbessay, Musa

AU - Ross, J C G

AU - Checchi, Francesco

AU - Youkee, Daniel

AU - Jalloh, Mohammed Boie

AU - Baion, David

AU - Mustapha, Ayeshatu

AU - Jah, Hawanatu

AU - Lako, Sandra

AU - Oza, Shefali

AU - Boufkhed, Sabah

AU - Feury, Reynold

AU - Bielicki, Julia A

AU - Gibb, Diana M

AU - Klein, Nigel

AU - Sahr, Foday

AU - Yeung, Shunmay

PY - 2016/10/1

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N2 - Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.

AB - Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Delivery of Health Care

KW - Disease Outbreaks

KW - Female

KW - Health Status

KW - Hemorrhagic Fever, Ebola/blood

KW - Humans

KW - Male

KW - Retrospective Studies

KW - Risk Factors

KW - Sierra Leone/epidemiology

KW - Treatment Outcome

U2 - 10.3201/eid2210.160579

DO - 10.3201/eid2210.160579

M3 - Article

C2 - 27649367

SN - 1080-6040

VL - 22

SP - 1769

EP - 1777

JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 10

ER -

Ebola Virus Disease in Children, Sierra Leone, 2014-2015

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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