Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

K Yu; Federico Roncaroli; T Kearney; D Ewins; D Beeharry; T Naylor; D Ray; R Bhalla; K Gnanalingham

doi:10.1007/s00701-017-3447-y

Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

K Yu , Federico Roncaroli, T Kearney , D Ewins , D Beeharry , T Naylor , D Ray , R Bhalla , K Gnanalingham

Division of Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient’s cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

Original language	English
Journal	Acta Neurochirurgica
DOIs	https://doi.org/10.1007/s00701-017-3447-y
Publication status	Published - 17 Jan 2018

Keywords

Pituitary adenoma
Cushing's syndrome
Ectopic

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10.1007/s00701-017-3447-y

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title = "Ectopic Cushing's syndrome secondary to olfactory neuroblastoma",

abstract = "We present the case of a patient with Cushing{\textquoteright}s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient{\textquoteright}s cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.",

keywords = "Pituitary adenoma, Cushing's syndrome, Ectopic",

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doi = "10.1007/s00701-017-3447-y",

language = "English",

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TY - JOUR

T1 - Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

AU - Yu , K

AU - Roncaroli, Federico

AU - Kearney , T

AU - Ewins , D

AU - Beeharry , D

AU - Naylor , T

AU - Ray , D

AU - Bhalla , R

AU - Gnanalingham , K

PY - 2018/1/17

Y1 - 2018/1/17

N2 - We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient’s cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

AB - We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient’s cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

KW - Pituitary adenoma

KW - Cushing's syndrome

KW - Ectopic

U2 - 10.1007/s00701-017-3447-y

DO - 10.1007/s00701-017-3447-y

M3 - Article

SN - 0001-6268

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

ER -

Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

Abstract

Keywords

UN SDGs

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