Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation

Yifen Liu; Jonathan D Schofield; Rahul Yadav; Salam Hama; Michael France; See Kwok; Deepak Bhatnagar; Edward Hinchliffe; Gilbert Wieringa; Paul Durrington; Handrean Soran

Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation

Yifen Liu, Jonathan D Schofield, Rahul Yadav, Salam Hama, Michael France, See Kwok, Deepak Bhatnagar, Edward Hinchliffe, Gilbert Wieringa, Paul Durrington, Handrean Soran

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Abstract

Aim: To investigate the influence of apoE genotype on the response to atorvastatin treatment in patients with Type 2 diabetes with nephropathy and the effect of niacin/laropiprant (LRPT) on apoE and glycated apoE concentration and distribution in hyperlipidaemia.Methods: ApoE genotype and the effect of 10mg/day and 80mg/day atorvastatin treatment on apoE concentration were studied in 85 patients with type 2 diabetes with nephropathy. The effect of niacin/LRPT on apoE and glycated apoE was investigated for 36 patients with hyperlipidaemia. Results: After 12 months treatment with atorvastatin, serum apoE concentration decreased significantly in the 80mg/day, but not the 10mg/day group. This decrease was observed in patients with E3 and E4 but not E2 genotype. Hyperlipidaemia did not affect total apoE, but the apoE distribution in HDL and d>1.21g/ml lipoprotein fractions was significantly lower. Glycated apoE was significantly higher in patients with hyperlipidaemia than healthy volunteers (p

Original language	English
Publication status	Published - Mar 2015
Event	EAS Congress2015 - Duration: 22 Mar 2015 → 25 Mar 2015

Conference

Conference	EAS Congress2015
Period	22/03/15 → 25/03/15

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@conference{a764138c1b4f48b3bdbdf9069f5ee267,

title = "Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation",

abstract = "Aim: To investigate the influence of apoE genotype on the response to atorvastatin treatment in patients with Type 2 diabetes with nephropathy and the effect of niacin/laropiprant (LRPT) on apoE and glycated apoE concentration and distribution in hyperlipidaemia.Methods: ApoE genotype and the effect of 10mg/day and 80mg/day atorvastatin treatment on apoE concentration were studied in 85 patients with type 2 diabetes with nephropathy. The effect of niacin/LRPT on apoE and glycated apoE was investigated for 36 patients with hyperlipidaemia. Results: After 12 months treatment with atorvastatin, serum apoE concentration decreased significantly in the 80mg/day, but not the 10mg/day group. This decrease was observed in patients with E3 and E4 but not E2 genotype. Hyperlipidaemia did not affect total apoE, but the apoE distribution in HDL and d>1.21g/ml lipoprotein fractions was significantly lower. Glycated apoE was significantly higher in patients with hyperlipidaemia than healthy volunteers (p",

author = "Yifen Liu and Schofield, {Jonathan D} and Rahul Yadav and Salam Hama and Michael France and See Kwok and Deepak Bhatnagar and Edward Hinchliffe and Gilbert Wieringa and Paul Durrington and Handrean Soran",

year = "2015",

month = mar,

language = "English",

note = "EAS Congress2015 ; Conference date: 22-03-2015 Through 25-03-2015",

}

TY - CONF

T1 - Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation

AU - Liu, Yifen

AU - Schofield, Jonathan D

AU - Yadav, Rahul

AU - Hama, Salam

AU - France, Michael

AU - Kwok, See

AU - Bhatnagar, Deepak

AU - Hinchliffe, Edward

AU - Wieringa, Gilbert

AU - Durrington, Paul

AU - Soran, Handrean

PY - 2015/3

Y1 - 2015/3

N2 - Aim: To investigate the influence of apoE genotype on the response to atorvastatin treatment in patients with Type 2 diabetes with nephropathy and the effect of niacin/laropiprant (LRPT) on apoE and glycated apoE concentration and distribution in hyperlipidaemia.Methods: ApoE genotype and the effect of 10mg/day and 80mg/day atorvastatin treatment on apoE concentration were studied in 85 patients with type 2 diabetes with nephropathy. The effect of niacin/LRPT on apoE and glycated apoE was investigated for 36 patients with hyperlipidaemia. Results: After 12 months treatment with atorvastatin, serum apoE concentration decreased significantly in the 80mg/day, but not the 10mg/day group. This decrease was observed in patients with E3 and E4 but not E2 genotype. Hyperlipidaemia did not affect total apoE, but the apoE distribution in HDL and d>1.21g/ml lipoprotein fractions was significantly lower. Glycated apoE was significantly higher in patients with hyperlipidaemia than healthy volunteers (p

AB - Aim: To investigate the influence of apoE genotype on the response to atorvastatin treatment in patients with Type 2 diabetes with nephropathy and the effect of niacin/laropiprant (LRPT) on apoE and glycated apoE concentration and distribution in hyperlipidaemia.Methods: ApoE genotype and the effect of 10mg/day and 80mg/day atorvastatin treatment on apoE concentration were studied in 85 patients with type 2 diabetes with nephropathy. The effect of niacin/LRPT on apoE and glycated apoE was investigated for 36 patients with hyperlipidaemia. Results: After 12 months treatment with atorvastatin, serum apoE concentration decreased significantly in the 80mg/day, but not the 10mg/day group. This decrease was observed in patients with E3 and E4 but not E2 genotype. Hyperlipidaemia did not affect total apoE, but the apoE distribution in HDL and d>1.21g/ml lipoprotein fractions was significantly lower. Glycated apoE was significantly higher in patients with hyperlipidaemia than healthy volunteers (p

M3 - Poster

T2 - EAS Congress2015

Y2 - 22 March 2015 through 25 March 2015

ER -

Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation

Abstract

Conference

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