Effect of Atorvastatin and Niacin/LRPT on Apolipoprotein E Distribution, Metabolism and Glycation

Yifen Liu, Jonathan D Schofield, Rahul Yadav, Salam Hama, Michael France, See Kwok, Deepak Bhatnagar, Edward Hinchliffe, Gilbert Wieringa, Paul Durrington, Handrean Soran

Research output: Contribution to conferencePoster


Aim: To investigate the influence of apoE genotype on the response to atorvastatin treatment in patients with Type 2 diabetes with nephropathy and the effect of niacin/laropiprant (LRPT) on apoE and glycated apoE concentration and distribution in hyperlipidaemia.Methods: ApoE genotype and the effect of 10mg/day and 80mg/day atorvastatin treatment on apoE concentration were studied in 85 patients with type 2 diabetes with nephropathy. The effect of niacin/LRPT on apoE and glycated apoE was investigated for 36 patients with hyperlipidaemia. Results: After 12 months treatment with atorvastatin, serum apoE concentration decreased significantly in the 80mg/day, but not the 10mg/day group. This decrease was observed in patients with E3 and E4 but not E2 genotype. Hyperlipidaemia did not affect total apoE, but the apoE distribution in HDL and d>1.21g/ml lipoprotein fractions was significantly lower. Glycated apoE was significantly higher in patients with hyperlipidaemia than healthy volunteers (p
Original languageEnglish
Publication statusPublished - Mar 2015
EventEAS Congress2015 -
Duration: 22 Mar 201525 Mar 2015


ConferenceEAS Congress2015


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