Effect of bariatric surgery on apolipoproteinE concentration and distribution

Yifen Liu, Jonathan D Schofield, Salam Hama, Rahul Yadav, Michael France, Basil J. Ammori, Paul N Durrington, Handrean Soran

    Research output: Contribution to conferencePoster

    Abstract

    Aim: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism. It is likely to have different functions in different lipoproteins, and glycation almost certainly affects its functionality. This study aimed to assess the effects of obesity on apoE concentration and distribution across lipoproteins, and its susceptibility to glycation, and discover the effect of weight loss after bariatric surgery.Methods: We studied total and glycated apoE, and the distribution of apoE across different lipoprotein sub-fractions in 20 non-obese and obese patients before and after bariatric surgery.Results: In obese patients total apoE and glycated apoE were higher compared with non-obese controls, at 59.5(27-108) vs. 46.7(30-88.5) mg/l (p1.21g/ml (13.3% vs. 16.5%, p0.05). Six months after bariatric surgery, total apoE decreased by 18.9%. The percentage apoE in VLDL increased by 31.6% (p1.21g/ml fractions (p
    Original languageEnglish
    Publication statusPublished - 2015
    EventEAS Congress2015 -
    Duration: 22 Mar 201525 Mar 2015

    Conference

    ConferenceEAS Congress2015
    Period22/03/1525/03/15

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