Effect of bariatric surgery on apolipoproteinE concentration and distribution

Yifen Liu; Jonathan D Schofield; Salam Hama; Rahul Yadav; Michael France; Basil J. Ammori; Paul N Durrington; Handrean Soran

Effect of bariatric surgery on apolipoproteinE concentration and distribution

Yifen Liu, Jonathan D Schofield, Salam Hama, Rahul Yadav, Michael France, Basil J. Ammori, Paul N Durrington, Handrean Soran

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Abstract

Aim: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism. It is likely to have different functions in different lipoproteins, and glycation almost certainly affects its functionality. This study aimed to assess the effects of obesity on apoE concentration and distribution across lipoproteins, and its susceptibility to glycation, and discover the effect of weight loss after bariatric surgery.Methods: We studied total and glycated apoE, and the distribution of apoE across different lipoprotein sub-fractions in 20 non-obese and obese patients before and after bariatric surgery.Results: In obese patients total apoE and glycated apoE were higher compared with non-obese controls, at 59.5(27-108) vs. 46.7(30-88.5) mg/l (p1.21g/ml (13.3% vs. 16.5%, p0.05). Six months after bariatric surgery, total apoE decreased by 18.9%. The percentage apoE in VLDL increased by 31.6% (p1.21g/ml fractions (p

Original language	English
Publication status	Published - 2015
Event	EAS Congress2015 - Duration: 22 Mar 2015 → 25 Mar 2015

Conference

Conference	EAS Congress2015
Period	22/03/15 → 25/03/15

Cite this

@conference{27a980cc54e94d71845d5beb396927ac,

title = "Effect of bariatric surgery on apolipoproteinE concentration and distribution",

abstract = "Aim: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism. It is likely to have different functions in different lipoproteins, and glycation almost certainly affects its functionality. This study aimed to assess the effects of obesity on apoE concentration and distribution across lipoproteins, and its susceptibility to glycation, and discover the effect of weight loss after bariatric surgery.Methods: We studied total and glycated apoE, and the distribution of apoE across different lipoprotein sub-fractions in 20 non-obese and obese patients before and after bariatric surgery.Results: In obese patients total apoE and glycated apoE were higher compared with non-obese controls, at 59.5(27-108) vs. 46.7(30-88.5) mg/l (p1.21g/ml (13.3% vs. 16.5%, p0.05). Six months after bariatric surgery, total apoE decreased by 18.9%. The percentage apoE in VLDL increased by 31.6% (p1.21g/ml fractions (p",

author = "Yifen Liu and Schofield, {Jonathan D} and Salam Hama and Rahul Yadav and Michael France and Ammori, {Basil J.} and Durrington, {Paul N} and Handrean Soran",

year = "2015",

language = "English",

note = "EAS Congress2015 ; Conference date: 22-03-2015 Through 25-03-2015",

}

TY - CONF

T1 - Effect of bariatric surgery on apolipoproteinE concentration and distribution

AU - Liu, Yifen

AU - Schofield, Jonathan D

AU - Hama, Salam

AU - Yadav, Rahul

AU - France, Michael

AU - Ammori, Basil J.

AU - Durrington, Paul N

AU - Soran, Handrean

PY - 2015

Y1 - 2015

N2 - Aim: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism. It is likely to have different functions in different lipoproteins, and glycation almost certainly affects its functionality. This study aimed to assess the effects of obesity on apoE concentration and distribution across lipoproteins, and its susceptibility to glycation, and discover the effect of weight loss after bariatric surgery.Methods: We studied total and glycated apoE, and the distribution of apoE across different lipoprotein sub-fractions in 20 non-obese and obese patients before and after bariatric surgery.Results: In obese patients total apoE and glycated apoE were higher compared with non-obese controls, at 59.5(27-108) vs. 46.7(30-88.5) mg/l (p1.21g/ml (13.3% vs. 16.5%, p0.05). Six months after bariatric surgery, total apoE decreased by 18.9%. The percentage apoE in VLDL increased by 31.6% (p1.21g/ml fractions (p

AB - Aim: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism. It is likely to have different functions in different lipoproteins, and glycation almost certainly affects its functionality. This study aimed to assess the effects of obesity on apoE concentration and distribution across lipoproteins, and its susceptibility to glycation, and discover the effect of weight loss after bariatric surgery.Methods: We studied total and glycated apoE, and the distribution of apoE across different lipoprotein sub-fractions in 20 non-obese and obese patients before and after bariatric surgery.Results: In obese patients total apoE and glycated apoE were higher compared with non-obese controls, at 59.5(27-108) vs. 46.7(30-88.5) mg/l (p1.21g/ml (13.3% vs. 16.5%, p0.05). Six months after bariatric surgery, total apoE decreased by 18.9%. The percentage apoE in VLDL increased by 31.6% (p1.21g/ml fractions (p

M3 - Poster

T2 - EAS Congress2015

Y2 - 22 March 2015 through 25 March 2015

ER -

Effect of bariatric surgery on apolipoproteinE concentration and distribution

Abstract

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