Effect of Body Mass Index on Outcome in Biliary tract cancer

MK Doherty, Mairead Mcnamara, P Aneja, L Le, S Cleary, AM Horgan, JJ Knox

    Research output: Contribution to conferencePoster


    Background: Biliary Tract Cancer (BTC) is associated with poor outcomes, and prognostic factors are not well documented. Body Mass Index (BMI) has been shown to correlate with survival in colon, breast, lung and prostate cancer. The effect of BMI on survival in patients with BTC is unclear. Greater understanding of prognostic markers in BTC can help with treatment decisions. Methods: Patients treated for BTC in Princess Margaret Cancer Centre between 06/1987 and 08/2014 were included for analysis. Data were collected on clinicopathologic features, BMI, and survival. Patients were separated into two groups by resectability: definitive surgery (DS) or no definitive surgery (NDS). Multivariable proportional hazards regression was used to investigate the association between variables and overall survival (OS) for DS and NDS groups. Results: 902 patients (461 DS, 441 NDS) were included, with median BMI 25.7 (range 15.5-48.7). Median OS was 48.1 months in DS patients and 11 months in NDS patients. 244 NDS patients received palliative chemotherapy (55%). BMI was prognostic for OS in DS patients. In univariate analysis, DS patients with BMI
    Original languageEnglish
    Publication statusPublished - 2015
    Event2015 Gastrointestinal Cancers Symposium - San Francisco
    Duration: 15 Jan 201517 Jan 2015


    Conference2015 Gastrointestinal Cancers Symposium
    CitySan Francisco


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