Effect of carbon dioxide on background cerebral electrical activity in preterm infants during the first 4 weeks after birth

A Raina, M Sarwar, A Hendrickson, S Victor

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Background: Hypocarbia causes slowing of background cerebral electrical activity while hypercarbia causes prolonged interburst intervals in very low birth weight babies during the first 3 days after birth1. Aim: This study aims to determine whether changes in blood gases were associated with changes in background cerebral electrical activity in preterm infants during the first four weeks after birth. Methods: An observational study is being conducted at the Newborn Intensive Care Unit, St Mary’s Hospital, Manchester. 75 minute electroencephalography (EEG) recordings were performed every week for 4 weeks in babies born before 32 weeks gestational age. Capillary blood gases were measured midway during each EEG recording. EEG was analysed by manual calculation of interburst interval. pH, pCO2, base deficit and bicarbonate were entered as variables in a stepwise linear regression model. Results: So far 39 EEG recordings have been performed on 13 babies recruited. The corrected gestational age at the time of EEG recording ranged from 24 – 34 weeks. The median (range) of blood gas measurements were: pH: 7.3 (7.18 – 7.43); partial pressure of carbon dioxide (pCO2): 6.68 kPa (5.06 – 10.2); Base deficit: 1.5 (8.9 to -10.7); Bicarbonate: 22.15 mmol/L (16.7 – 33.1). Corrected gestational age was related to duration of interburst interval (r = 0.699; p
    Original languageEnglish
    Title of host publicationPediatric research
    PublisherSpringer Nature
    Publication statusPublished - Oct 2010
    EventEuropean Academy of Paediatric Societies - Copenhagen
    Duration: 23 Oct 201026 Oct 2010

    Conference

    ConferenceEuropean Academy of Paediatric Societies
    CityCopenhagen
    Period23/10/1026/10/10

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