Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis

Steven T. Haller; Philip A. Kalra; James P. Ritchie; Tina Chrysochou; Pamela Brewster; Wencan He; Haifeng Yu; Joseph I. Shapiro; Christopher J. Cooper

doi:10.1161/HYPERTENSIONAHA.111.00685

Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis

Steven T. Haller, Philip A. Kalra, James P. Ritchie, Tina Chrysochou, Pamela Brewster, Wencan He, Haifeng Yu, Joseph I. Shapiro, Christopher J. Cooper

Research output: Contribution to journal › Article › peer-review

Abstract

Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme-linked immunosorbent assay in a single center cohort of 60 patients with renal artery stenosis recruited from Salford Royal Hospital, Manchester, United Kingdom. A natural log transformation of CD40 and soluble CD40 ligand was performed to normalize the data. Estimated glomerular filtration rate was used as the primary indicator of renal function. By univariate analysis, low baseline levels of circulating CD40 (R=0.06; P

Original language	English
Pages (from-to)	894-900
Number of pages	6
Journal	Hypertension
Volume	61
Issue number	4
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.111.00685
Publication status	Published - Apr 2013

Keywords

CD40
renal artery stenosis
renal artery stenting
renal function
soluble CD40 ligand

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10.1161/HYPERTENSIONAHA.111.00685

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title = "Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis",

abstract = "Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme-linked immunosorbent assay in a single center cohort of 60 patients with renal artery stenosis recruited from Salford Royal Hospital, Manchester, United Kingdom. A natural log transformation of CD40 and soluble CD40 ligand was performed to normalize the data. Estimated glomerular filtration rate was used as the primary indicator of renal function. By univariate analysis, low baseline levels of circulating CD40 (R=0.06; P",

keywords = "CD40, renal artery stenosis, renal artery stenting, renal function, soluble CD40 ligand",

author = "Haller, {Steven T.} and Kalra, {Philip A.} and Ritchie, {James P.} and Tina Chrysochou and Pamela Brewster and Wencan He and Haifeng Yu and Shapiro, {Joseph I.} and Cooper, {Christopher J.}",

year = "2013",

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language = "English",

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T1 - Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis

AU - Haller, Steven T.

AU - Kalra, Philip A.

AU - Ritchie, James P.

AU - Chrysochou, Tina

AU - Brewster, Pamela

AU - He, Wencan

AU - Yu, Haifeng

AU - Shapiro, Joseph I.

AU - Cooper, Christopher J.

PY - 2013/4

Y1 - 2013/4

N2 - Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme-linked immunosorbent assay in a single center cohort of 60 patients with renal artery stenosis recruited from Salford Royal Hospital, Manchester, United Kingdom. A natural log transformation of CD40 and soluble CD40 ligand was performed to normalize the data. Estimated glomerular filtration rate was used as the primary indicator of renal function. By univariate analysis, low baseline levels of circulating CD40 (R=0.06; P

AB - Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme-linked immunosorbent assay in a single center cohort of 60 patients with renal artery stenosis recruited from Salford Royal Hospital, Manchester, United Kingdom. A natural log transformation of CD40 and soluble CD40 ligand was performed to normalize the data. Estimated glomerular filtration rate was used as the primary indicator of renal function. By univariate analysis, low baseline levels of circulating CD40 (R=0.06; P

KW - CD40

KW - renal artery stenosis

KW - renal artery stenting

KW - renal function

KW - soluble CD40 ligand

U2 - 10.1161/HYPERTENSIONAHA.111.00685

DO - 10.1161/HYPERTENSIONAHA.111.00685

M3 - Article

SN - 1524-4563

VL - 61

SP - 894

EP - 900

JO - Hypertension

JF - Hypertension

IS - 4

ER -

Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis

Abstract

Keywords

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