Effect of changes in arterial-mixed venous oxygen content difference (C(a-v̄)O2) on indices of pulmonary oxygen transfer in a model ARDS lung

M. Nirmalan; T. Willard; M. O. Columb; P. Nightingale

doi:10.1093/bja/86.4.477

Effect of changes in arterial-mixed venous oxygen content difference (C(a-v̄)O2) on indices of pulmonary oxygen transfer in a model ARDS lung

M. Nirmalan, T. Willard, M. O. Columb, P. Nightingale

Research output: Contribution to journal › Article › peer-review

Abstract

Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v̄)O2. Though variations in C(a-v̄)O2 are recognized, indices such as PaO2/FlO2 remain popular and are often considered the best measure of pulmonary oxygen transfer in critically ill patients. This study estimated the effect of within-subject variations in C(a-v̄)O2 and FlO2 on venous admixture (Qs/Qt), the calculated oxygen content difference between end-capillary and arterial blood (Cc′ O2-CaO2), the alveolar-arterial oxygen tension gradient (P(A-a)O2) and PaO2/FlO2, using a validated lung model of acute respiratory distress syndrome (ARDS). All four indices showed changes with FlO2 and C(a-v̄)O2, although the magnitude of changes in Qs/Qt was clinically unimportant (

Original language	English
Pages (from-to)	477-485
Number of pages	8
Journal	British Journal of Anaesthesia
Volume	86
Issue number	4
DOIs	https://doi.org/10.1093/bja/86.4.477
Publication status	Published - 2001

Keywords

Complications, acute respiratory distress syndrome
Complications, hypoxaemia
Lung, blood flow
Lung, damage
Model, lung
Oxygen, consumption
Oxygen, measurement
Ventilation
Ventilation, ventilation-perfusion

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10.1093/bja/86.4.477

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title = "Effect of changes in arterial-mixed venous oxygen content difference (C(a-{\=v})O2) on indices of pulmonary oxygen transfer in a model ARDS lung",

abstract = "Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-{\=v})O2. Though variations in C(a-{\=v})O2 are recognized, indices such as PaO2/FlO2 remain popular and are often considered the best measure of pulmonary oxygen transfer in critically ill patients. This study estimated the effect of within-subject variations in C(a-{\=v})O2 and FlO2 on venous admixture (Qs/Qt), the calculated oxygen content difference between end-capillary and arterial blood (Cc′ O2-CaO2), the alveolar-arterial oxygen tension gradient (P(A-a)O2) and PaO2/FlO2, using a validated lung model of acute respiratory distress syndrome (ARDS). All four indices showed changes with FlO2 and C(a-{\=v})O2, although the magnitude of changes in Qs/Qt was clinically unimportant (",

keywords = "Complications, acute respiratory distress syndrome, Complications, hypoxaemia, Lung, blood flow, Lung, damage, Model, lung, Oxygen, consumption, Oxygen, measurement, Ventilation, Ventilation, ventilation-perfusion",

author = "M. Nirmalan and T. Willard and Columb, {M. O.} and P. Nightingale",

year = "2001",

doi = "10.1093/bja/86.4.477",

language = "English",

volume = "86",

pages = "477--485",

journal = "British Journal of Anaesthesia",

issn = "0007-0912",

publisher = "Elsevier BV",

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T1 - Effect of changes in arterial-mixed venous oxygen content difference (C(a-v̄)O2) on indices of pulmonary oxygen transfer in a model ARDS lung

AU - Nirmalan, M.

AU - Willard, T.

AU - Columb, M. O.

AU - Nightingale, P.

PY - 2001

Y1 - 2001

N2 - Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v̄)O2. Though variations in C(a-v̄)O2 are recognized, indices such as PaO2/FlO2 remain popular and are often considered the best measure of pulmonary oxygen transfer in critically ill patients. This study estimated the effect of within-subject variations in C(a-v̄)O2 and FlO2 on venous admixture (Qs/Qt), the calculated oxygen content difference between end-capillary and arterial blood (Cc′ O2-CaO2), the alveolar-arterial oxygen tension gradient (P(A-a)O2) and PaO2/FlO2, using a validated lung model of acute respiratory distress syndrome (ARDS). All four indices showed changes with FlO2 and C(a-v̄)O2, although the magnitude of changes in Qs/Qt was clinically unimportant (

AB - Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v̄)O2. Though variations in C(a-v̄)O2 are recognized, indices such as PaO2/FlO2 remain popular and are often considered the best measure of pulmonary oxygen transfer in critically ill patients. This study estimated the effect of within-subject variations in C(a-v̄)O2 and FlO2 on venous admixture (Qs/Qt), the calculated oxygen content difference between end-capillary and arterial blood (Cc′ O2-CaO2), the alveolar-arterial oxygen tension gradient (P(A-a)O2) and PaO2/FlO2, using a validated lung model of acute respiratory distress syndrome (ARDS). All four indices showed changes with FlO2 and C(a-v̄)O2, although the magnitude of changes in Qs/Qt was clinically unimportant (

KW - Complications, acute respiratory distress syndrome

KW - Complications, hypoxaemia

KW - Lung, blood flow

KW - Lung, damage

KW - Model, lung

KW - Oxygen, consumption

KW - Oxygen, measurement

KW - Ventilation

KW - Ventilation, ventilation-perfusion

U2 - 10.1093/bja/86.4.477

DO - 10.1093/bja/86.4.477

M3 - Article

SN - 0007-0912

VL - 86

SP - 477

EP - 485

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 4

ER -

Effect of changes in arterial-mixed venous oxygen content difference (C(a-v̄)O2) on indices of pulmonary oxygen transfer in a model ARDS lung

Abstract

Keywords

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