Effect of depot medroxyprogesterone acetate and testosterone oenanthate on serum lipoproteins in man

E M Wallace, F C Wu

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Ten normal men were given three monthly intramuscular injections of 200mg of depot medroxyprogesterone acetate (DMPA) and 250mg of testosterone oenanthate (TE) as part of a male contraceptive trial. During the three months of treatment, serum high density lipoprotein cholesterol (HDL-C) and the HDL-C:LDL-C (low density lipoprotein cholesterol) ratio were significantly depressed compared to baseline. Although the long-term effect of this alteration in lipoprotein cholesterol metabolism in normolipidaemic men is currently uncertain, these results suggest that the potential cardiovascular risks of progestagen-containing regimens for male contraception will have to be seriously considered.
    Original languageEnglish
    Pages (from-to)63-71
    Number of pages9
    JournalContraception
    Volume41
    Issue number1
    Publication statusPublished - 1990

    Keywords

    • Adult
    • Cholesterol, HDL/blood
    • Cholesterol, LDL/blood
    • *Contraceptive Agents, Male
    • Humans
    • Lipoproteins/*blood
    • Male
    • Medroxyprogesterone/*analogs & derivatives
    • Medroxyprogesterone Acetate
    • Testosterone/*analogs & derivatives

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