Effect of different asthma treatments on risk of cold-related exacerbations

H. K. Reddel, C. Jenkins, S. Quirce, M. R. Sears, E. D. Bateman, P. M. O'Byrne, M. Humbert, R. Buhl, T. Harrison, G. G. Brusselle, A. Thorén, U. Sjöbring, S. Peterson, O. Östlund, G. S. Eriksson

    Research output: Contribution to journalArticlepeer-review


    Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting β 2-agonists (LABA), and with as-needed short-acting β 2-agonists (SABA) or LABA. Reported colds and severe exacerbations (defined by oral corticosteroid use and/or hospitalisation/emergency room visit) were assessed for 12,507 patients during 6-12 months of double-blind treatment. Exacerbations occurring ≤14 days after onset of reported colds were analysed by a Poisson model. The incidence of colds was similar across treatments. Asthma symptoms and reliever use increased during colds. Budesonide/formoterol maintenance and reliever therapy reduced severe cold-related exacerbations by 36% versus pooled comparators plus SABA (rate ratio (RR) 0.64; p=0.002), and for individual treatment comparisons, by 52% versus the same maintenance dose of ICS/LABA (RR 0.48; p
    Original languageEnglish
    Pages (from-to)584-593
    Number of pages9
    JournalEuropean Respiratory Journal
    Issue number3
    Publication statusPublished - Sep 2011


    • Asthma
    • Drug therapy
    • Exacerbations
    • Respiratory tract infections


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