Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

Graham Taylor; Pablo Cordano; Annette Lake; Lesley Shield; G. M. Taylor; Freda E. Alexander; Penelope R A Taylor; Jo White; Ruth F. Jarrett

doi:10.1111/j.1365-2141.2004.05353.x

Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

Graham Taylor
, Pablo Cordano
, Annette Lake
, Lesley Shield
, G. M. Taylor
, Freda E. Alexander
, Penelope R A Taylor
, Jo White
, Ruth F. Jarrett

Research output: Contribution to journal › Article › peer-review

Abstract

A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.

Original language	English
Pages (from-to)	493-495
Number of pages	2
Journal	British Journal of Haematology
Volume	128
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2004.05353.x
Publication status	Published - Feb 2005

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hodgkin's lymphoma
IL-6
Single nucleotide polymorphism

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10.1111/j.1365-2141.2004.05353.x

Cite this

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title = "Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma",

abstract = "A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.",

keywords = "Hodgkin's lymphoma, IL-6, Single nucleotide polymorphism",

author = "Graham Taylor and Pablo Cordano and Annette Lake and Lesley Shield and Taylor, \{G. M.\} and Alexander, \{Freda E.\} and Taylor, \{Penelope R A\} and Jo White and Jarrett, \{Ruth F.\}",

year = "2005",

month = feb,

doi = "10.1111/j.1365-2141.2004.05353.x",

language = "English",

volume = "128",

pages = "493--495",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley \& Sons Ltd",

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TY - JOUR

T1 - Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

AU - Taylor, Graham

AU - Cordano, Pablo

AU - Lake, Annette

AU - Shield, Lesley

AU - Taylor, G. M.

AU - Alexander, Freda E.

AU - Taylor, Penelope R A

AU - White, Jo

AU - Jarrett, Ruth F.

PY - 2005/2

Y1 - 2005/2

N2 - A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.

AB - A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.

KW - Hodgkin's lymphoma

KW - IL-6

KW - Single nucleotide polymorphism

U2 - 10.1111/j.1365-2141.2004.05353.x

DO - 10.1111/j.1365-2141.2004.05353.x

M3 - Article

SN - 0007-1048

VL - 128

SP - 493

EP - 495

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

Abstract

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Keywords

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